High neutrophil-to-lymphocyte ratio is an independent marker of poor disease-specific survival in patients with oral cancer

With growing evidence on the role of inflammation in carcinogenesis, the presence of a systemic inflammatory response has been proposed as having prognostic significance in a wide range of cancers. The aim of the study was to assess the value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in p...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2013-03, Vol.30 (1), p.334-8, Article 334
Main Authors: Perisanidis, Christos, Kornek, Gabriela, Pöschl, Paul W., Holzinger, Daniel, Pirklbauer, Katharina, Schopper, Christian, Ewers, Rolf
Format: Article
Language:English
Subjects:
Area Under Curve
Carcinogenesis
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Disease-Free Survival
Female
Hematology
Humans
Internal Medicine
Kaplan-Meier Estimate
Lymphocytes - pathology
Lymphocytes, Tumor-Infiltrating - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - immunology
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Neoplasm Staging
Neutrophils - pathology
Oncology
Original Paper
Pathology
Prognosis
ROC Curve
Sensitivity and Specificity
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Summary:With growing evidence on the role of inflammation in carcinogenesis, the presence of a systemic inflammatory response has been proposed as having prognostic significance in a wide range of cancers. The aim of the study was to assess the value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in predicting disease-specific survival (DSS) in patients with oral cancer undergoing preoperative chemoradiotherapy. A cohort of 97 patients with locally advanced oral squamous cell carcinoma receiving preoperative chemoradiotherapy was retrospectively examined. The impact of NLR and other potential prognostic factors on DSS was assessed with the Kaplan–Meier method and multivariate Cox regression analysis. Sixty-nine patients had a high pretreatment NLR, with NLR > 1.9 considered as high according to receiver operating characteristic curve analysis. In univariate analysis, high pretreatment NLR ( p  = 0.018), positive perineural invasion ( p  
ISSN:1357-0560
1559-131X
DOI:10.1007/s12032-012-0334-5