Chromosomal abnormalities by conventional cytogenetics and interphase fluorescence in situ hybridization in chronic lymphocytic leukemia in Taiwan, an area with low incidence—clinical implication and comparison between the West and the East

Chronic lymphocytic leukemia (CLL) is much less prevalent in Taiwan than in the West, but we have recently addressed the distinctly increasing incidence of CLL in Taiwan. We sought to find out whether there is any difference in cytogenetic abnormalities (CA) of CLL between the West and the East. We...

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Bibliographic Details
Published in:Annals of hematology 2013-06, Vol.92 (6), p.799-806
Main Authors: Wu, Shang-Ju, Lin, Chien-Ting, Huang, Sheng-Yi, Lee, Fen-Yu, Liu, Ming-Chi, Hou, Hsin-An, Chen, Chien-Yuan, Ko, Bor-Sheng, Chou, Wen-Chien, Yao, Ming, Tang, Jih-Luh, Tsay, Woei, Tien, Hwei-Fang
Format: Article
Language:English
Subjects:
Aged
Aneuploidy
Asian Continental Ancestry Group - statistics & numerical data
Bone Marrow Examination - methods
Chromosome Aberrations
Chromosome Banding
Chromosomes, Human, Pair 3 - genetics
European Continental Ancestry Group - statistics & numerical data
Female
Hematology
Humans
In Situ Hybridization, Fluorescence - methods
Incidence
Interphase
Kaplan-Meier Estimate
Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Prognosis
Taiwan - epidemiology
Trisomy
United States - epidemiology
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Summary:Chronic lymphocytic leukemia (CLL) is much less prevalent in Taiwan than in the West, but we have recently addressed the distinctly increasing incidence of CLL in Taiwan. We sought to find out whether there is any difference in cytogenetic abnormalities (CA) of CLL between the West and the East. We analyze the CA, by conventional cytogenetics (CG) and fluorescence in situ hybridization (FISH), and their clinical significance in 83 Taiwanese CLL patients and compared the data to those of Western countries. Thirty-five patients (42.2 %) possessed CG-CA and 58 (69.9 %) FISH-CA. By either CG or FISH, deletion of 17p or 11q was associated with poorer overall survival (OS) ( P  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-013-1700-x