Measuring and modelling cell-to-cell variation in uptake of gold nanoparticles

The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mas...

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Bibliographic Details
Published in:Analyst (London) 2013-12, Vol.138 (23), p.7070-7074
Main Authors: Jeynes, J Charles G, Jeynes, Christopher, Merchant, Michael J, Kirkby, Karen J
Format: Article
Language:English
Subjects:
Gold
Gold - chemistry
Mathematical models
Metal Nanoparticles
Modelling
Models, Biological
Nanoparticles
Serums
Uptakes
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Summary:The cell-to-cell variation of gold nanoparticle (GNP) uptake is important for therapeutic applications. We directly counted the GNPs in hundreds of individual cells, and showed that the large variation from cell-to-cell could be directly modelled by assuming log-normal distributions of both cell mass and GNP rate of uptake. This was true for GNPs non-specifically bound to fetal bovine serum or conjugated to a cell penetrating peptide. Within a population of cells, GNP content varied naturally by a factor greater than 10 between individual cells.
ISSN:0003-2654
1364-5528
DOI:10.1039/c3an01406a