Antidyslipidemic and antioxidant activity of an unusual amino acid (2-amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea

• Published in: Phytomedicine (Stuttgart) 2013-12, Vol.21 (1), p.15-19
• Main Authors: Prasad, Janki, Singh, Vinay Kr, Shrivastava, Atul, Chaturvedi, Upma, Bhatia, Gitika, Arya, K.R., Awasthi, S.K., Narender, T.
• Format: Article
• Language: English
• Subjects: Animals; Anticholesteremic agents; Antidyslipidemic activity; Antioxidant activity; Antioxidants; Antioxidants - isolation & purification; Antioxidants - pharmacology; Antioxidants - therapeutic use; Caproates - isolation & purification; Caproates - pharmacology; Caproates - therapeutic use; Crotalaria - chemistry; Crotalaria juncea; Dose-Response Relationship, Drug; Health aspects; Hyperlipidemias - blood; Hyperlipidemias - chemically induced; Hyperlipidemias - drug therapy; Hypolipidemic Agents - isolation & purification; Hypolipidemic Agents - pharmacology; Hypolipidemic Agents - therapeutic use; Lipids - blood; Medicinal plants; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Rats; Seeds - chemistry; Triton model
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1016/j.phymed.2013.08.004

In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1.