The TGF-B1 and IL-10 gene polymorphisms are associated with risk of developing silent myocardial ischemia in the diabetic patients

Highlights • The IL-10-1082 (rs1800896), TGF-β1-509 (rs1800469), and TGF-β1 T29C (rs1800470) SNPs play an important role in the risk of developing SMI. • In our study, it was possible to distinguish two protective haplotypes in TGF-β1 for SMI development. • Based on SNP functional prediction softwar...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2013-11, Vol.156 (1), p.18-22
Main Authors: Cruz, Miguel, Fragoso, José Manuel, Alvarez-León, Edith, Escobedo-de-la-Peña, Jorge, Valladares, Adan, Juárez-Cedillo, Teresa, Pérez-Méndez, Oscar, Vargas-Alarcón, Gilberto
Format: Article
Language:English
Subjects:
Aged
Allergy and Immunology
Comorbidity
Diabetes Mellitus - epidemiology
Female
Gene Frequency
Genetic Predisposition to Disease - genetics
Genetic susceptibility
Genotype
Haplotypes
Humans
Interleukin 10
Interleukin-10 - genetics
Linkage Disequilibrium
Male
Mexico - epidemiology
Middle Aged
Myocardial Ischemia - epidemiology
Myocardial Ischemia - genetics
Polymorphism, Single Nucleotide
Polymorphisms
Risk Factors
Silent myocardial ischemia
Transforming Growth Factor beta1 - genetics
Transforming growth factor-β1
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • The IL-10-1082 (rs1800896), TGF-β1-509 (rs1800469), and TGF-β1 T29C (rs1800470) SNPs play an important role in the risk of developing SMI. • In our study, it was possible to distinguish two protective haplotypes in TGF-β1 for SMI development. • Based on SNP functional prediction software, the IL-10-1082 (rs1800896) and TGF-β1 T29C (rs1800470) SNPs seem to be functional.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2013.09.007