Definitions and Pathophysiology of Sepsis

Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. This series of review articles will discuss th...

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Bibliographic Details
Published in:Current problems in pediatric and adolescent health care 2013-11, Vol.43 (10), p.260-263
Main Authors: Sagy, Mayer, MD, Al-Qaqaa, Yasir, MD, Kim, Paul, MD
Format: Article
Language:English
Subjects:
Adolescent
Anti-Bacterial Agents - therapeutic use
Anti-Inflammatory Agents - therapeutic use
Child
Comorbidity
Fluid Therapy - methods
Humans
Inflammation - immunology
Inflammation - physiopathology
Inflammation Mediators - immunology
Multiple Organ Failure - immunology
Multiple Organ Failure - physiopathology
Pediatrics
Practice Guidelines as Topic
Resuscitation - methods
Sepsis - drug therapy
Sepsis - immunology
Sepsis - physiopathology
Severe Acute Respiratory Syndrome - immunology
Severe Acute Respiratory Syndrome - physiopathology
Severity of Illness Index
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Description
Summary:Mortality rates for sepsis and septic shock have not improved in the past decade. The Surviving Sepsis Campaign (SSC) guidelines released in 2012 emphasize early recognition and treatment of sepsis, in an effort to reduce the burden of sepsis worldwide. This series of review articles will discuss the pathophysiology of sepsis; comorbidities, such as multiorgan dysfunction syndrome (MODS), acute respiratory distress syndrome (ARDS), and endocrine issues; and finally, management of sepsis and septic shock.
ISSN:1538-5442
1538-3199
DOI:10.1016/j.cppeds.2013.10.001