Free Radical Lipid Peroxidation in the Nuclei of Mouse Liver Cells under Normal Conditions and after Partial Hepatectomy

The dynamics and periodicity of LPO processes in the nuclei and chromatin were detected during regenerative processes in mouse liver. LPO processes were enhanced in transcriptionally active and replicating chromatin. Phosphatidylcholine, phosphatidylinositol, esterified cholesterol, and free fatty a...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-08, Vol.155 (4), p.436-438
Main Authors: Trofimov, V. A., Aksenova, O. N., Dudko, A. A., Lopukhova, E. N., Trofimov, A. V.
Format: Article
Language:English
Subjects:
Animals
Animals, Outbred Strains
Antioxidants
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Nucleus - metabolism
Cell Proliferation
Chromatin - metabolism
DNA Replication
Enzymes
Fatty acids
Hepatectomy
Hepatocytes - physiology
Internal Medicine
Laboratory Medicine
Lipid Peroxidation
Liver - cytology
Liver - physiology
Liver Regeneration
Membrane lipids
Mice
Pathology
Phospholipids - metabolism
Thiobarbituric Acid Reactive Substances - metabolism
Transcription, Genetic
Citations: Items that this one cites
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Summary:The dynamics and periodicity of LPO processes in the nuclei and chromatin were detected during regenerative processes in mouse liver. LPO processes were enhanced in transcriptionally active and replicating chromatin. Phosphatidylcholine, phosphatidylinositol, esterified cholesterol, and free fatty acids were maximally oxidized during active transcription, and cardiolipin was oxidized during active replication. These processes were accompanied by periodical changes in activity of antioxidant enzymes. High activity of SOD during transcriptional activity of liver cells was typical for nuclear matrix-attached chromatin, but this parameter decreased during replication. Catalase activity signifi cantly increased in the fractions of highsalt chromatin and nuclear matrix-bound chromatin during replication.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2171-8