Molecular alterations and clinical relevance in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens duri...

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Bibliographic Details
Published in:Frontiers of medicine 2013-12, Vol.7 (4), p.401-410
Main Authors: Shang, Li, Wang, Mingrong
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - classification
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - metabolism
early detection
Early Detection of Cancer
Epigenesis, Genetic
Esophageal cancer
Esophageal Neoplasms - classification
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - genetics
Esophageal Neoplasms - metabolism
Esophageal Squamous Cell Carcinoma
esophageal squamous cell carcinoma (ESCC)
Esophagus
Gene Expression Regulation, Neoplastic
Genetic Markers
Genetic Predisposition to Disease
Humans
Medicine
Medicine & Public Health
MicroRNAs - metabolism
molecular classification
molecular markers
Polymorphism, Genetic
Prognosis
Review
Squamous cell carcinoma
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Summary:Esophageal squamous cell carcinoma (ESCC) is one of the most common types of gastrointestinal cancers, and the fourth leading cause of cancer-related deaths in China. Early detection and intervention in time may dramatically increase the survival of the patients by initiating treatment regimens during earlier stages of ESCC or even during precancerous stages. Molecular classification will be useful for subtyping esophageal tumors or precancerous lesions to improve current therapeutics or early intervention of the disease. In this review, we summarize the findings in investigating the molecular alterations and clinical relevance of ESCC.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-013-0286-y