Comparative metabolism of [3H]psoralen and [3H]isopsoralen by black swallowtail (Papilio polyxenes Fabr.) caterpillars

The comparative fate of tritiated preparations of a linear furanocoumarin (psoralen) and an angular furanocoumarin (isopsoralen) was determined in last-instar caterpillars of the black swallowtail butterfly (Papilio polyxenes Fabr.). Oral administration of either furanocoumarin at 5 μg/g is followed...

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Bibliographic Details
Published in:Journal of chemical ecology 1986-04, Vol.12 (4), p.871-884
Main Authors: Ivie, G.W, Bull, D.L, Beier, R.C, Pryor, N.W
Format: Article
Language:English
Subjects:
Biochemistry. Physiology. Immunology
Biological and medical sciences
COMPOSICION
COMPOSITION
COUMARINE
COUMARINS
CUMARINAS
DESINTOXICACION
DETOXIFICATION
Fundamental and applied biological sciences. Psychology
Insecta
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Invertebrates
METABOLISM
METABOLISME
METABOLISMO
PAPILIO
Physiology. Development
PLANTAS
PLANTE
PLANTS
TOXICIDAD
TOXICITE
TOXICITY
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Summary:The comparative fate of tritiated preparations of a linear furanocoumarin (psoralen) and an angular furanocoumarin (isopsoralen) was determined in last-instar caterpillars of the black swallowtail butterfly (Papilio polyxenes Fabr.). Oral administration of either furanocoumarin at 5 μg/g is followed by rapid metabolism, primarily through oxidative cleavage of the furan ring, and the metabolites are rapidly excreted. Isopsoralen is, however, metabolized at a somewhat slower rate than is psoralen, and levels of unmetabolized isopsoralen in body tissues of the treated caterpillars are about three-fold higher. These data are compatible with the hypothesis that a reduced detoxification rate accounts at least in part for the susceptibility ofP. polyxenes caterpillars to the deleterious effect of isopsoralens.
ISSN:0098-0331
1573-1561
DOI:10.1007/BF01020257