In vitro metabolism of a linear furanocoumarin (8-methoxypsoralen, xanthotoxin) by mixed-function oxidases of larvae of black swallowtail butterfly and fall armyworm

Studies were made of the comparative in vitro metabolism of [(14)C]xanthotoxin and [(14)C]aldrin by homogenate preparations of midguts and bodies (carcass minus digestive tract and head) of last-stage larvae of the black swallowtail butterfly (Papilio polyxenes Fabr.) and the fall armyworm [Spodopte...

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Bibliographic Details
Published in:Journal of chemical ecology 1986-04, Vol.12 (4), p.885-892
Main Authors: Bull, D.L, Ivie, G.W, Beier, R.C, Pryor, N.W
Format: Article
Language:English
Subjects:
Biochemistry. Physiology. Immunology
Biological and medical sciences
COUMARINE
COUMARINS
CUMARINAS
Fundamental and applied biological sciences. Psychology
Insecta
INSECTICIDAS
INSECTICIDE
INSECTICIDES
Invertebrates
LARVAE
LARVAS
LARVE
METABOLISM
METABOLISME
METABOLISMO
OXIDOREDUCTASES
OXIDORREDUCTASAS
OXYDOREDUCTASE
PAPILIO
PETROSELINUM
Physiology. Development
SPODOPTERA
SPODOPTERA FRUGIPERDA
TOXICIDAD
TOXICITE
TOXICITY
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Summary:Studies were made of the comparative in vitro metabolism of [(14)C]xanthotoxin and [(14)C]aldrin by homogenate preparations of midguts and bodies (carcass minus digestive tract and head) of last-stage larvae of the black swallowtail butterfly (Papilio polyxenes Fabr.) and the fall armyworm [Spodoptera frugiperda (J. E. Smith)]. The two substrates were metabolized by 10,000g supernatant microsomal preparations from both species. Evidence gained through the use of a specific inhibitor and cofactor indicated that mixed-function microsomal oxidases were major factors in the metabolism and that the specific activity of this enzyme system was considerably higher in midgut preparations fromP. polyxenes than in similar preparations fromS. frugiperda. Aldrin was metabolized 3-4 times faster byP. polyxenes, and xanthotoxin 6-6.5 times faster.
ISSN:0098-0331
1573-1561
DOI:10.1007/BF01020258