Biopolymeric Film Containing Bioactive Naphthoquinone (Shikonin) in Combined Therapy of Inflammatory Destructive Lesions in the Buccal Mucosa

Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patien...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-12, Vol.156 (2), p.232-235
Main Authors: Zagorodnyaya, E. B., Oskol’skii, G. I., Basharov, A. Ya, Lushnikova, E. L., Nepomnyashchikh, L. M., Zagorodnii, A. S.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biomedical and Life Sciences
Biomedicine
Biopolymers - therapeutic use
Cell Biology
Drugs, Chinese Herbal - therapeutic use
Female
Humans
Inflammation - drug therapy
Internal Medicine
Laboratory Medicine
Leukoplakia, Oral - drug therapy
Lichen Planus, Oral - drug therapy
Male
Methylcellulose
Methylcellulose - analogs & derivatives
Methylcellulose - therapeutic use
Middle Aged
Mouth Mucosa - pathology
Naphthoquinones - therapeutic use
Oral Ulcer - drug therapy
Pathology
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Summary:Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2318-7