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Biopolymeric Film Containing Bioactive Naphthoquinone (Shikonin) in Combined Therapy of Inflammatory Destructive Lesions in the Buccal Mucosa
Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from Lithospermum erythrorhizon L. cell culture. Combined therapy of 30 patien...
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| Published in: | Bulletin of experimental biology and medicine 2013-12, Vol.156 (2), p.232-235 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| cited_by | cdi_FETCH-LOGICAL-c470t-2bb096aa201e9c465c6a1a9e688be4f1c49345e34c37f94b729c70cff7c01a403 |
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| cites | cdi_FETCH-LOGICAL-c470t-2bb096aa201e9c465c6a1a9e688be4f1c49345e34c37f94b729c70cff7c01a403 |
| container_end_page | 235 |
| container_issue | 2 |
| container_start_page | 232 |
| container_title | Bulletin of experimental biology and medicine |
| container_volume | 156 |
| creator | Zagorodnyaya, E. B. Oskol’skii, G. I. Basharov, A. Ya Lushnikova, E. L. Nepomnyashchikh, L. M. Zagorodnii, A. S. |
| description | Clinical morphological efficiency of local application of a new biopolymeric film was studied. The film was based on methylcellulose derivatives and contained shikonin (preparation of plant origin) and its esters isolated from
Lithospermum
erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population. |
| doi_str_mv | 10.1007/s10517-013-2318-7 |
| format | article |
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Lithospermum
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Lithospermum
erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biopolymers - therapeutic use</subject><subject>Cell Biology</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation - drug therapy</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Leukoplakia, Oral - drug therapy</subject><subject>Lichen Planus, Oral - drug therapy</subject><subject>Male</subject><subject>Methylcellulose</subject><subject>Methylcellulose - analogs & derivatives</subject><subject>Methylcellulose - therapeutic use</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - pathology</subject><subject>Naphthoquinones - therapeutic use</subject><subject>Oral Ulcer - drug therapy</subject><subject>Pathology</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1ks1u1DAUhSMEokPhAdggS0ioLFL8FztZtgOFSgMsKGvL8dxMXBI7tR2keQjeGUdTqhaBvLDs-53je61TFC8JPiUYy3eR4IrIEhNWUkbqUj4qVqSSrKwpJY-LFc5Qyeu6PiqexXi9HLEgT4sjyhlpZCVWxa9z6yc_7EcI1qALO4xo7V3S1lm3Q7moTbI_AX3RU596fzNb5x2gk2-9_eEz8xZZlxVjax1s0VUPQU975Dt06bpBj6NOPuzRe4gpzAenDUTrXVx0qQd0PhujB_R5Nj7q58WTTg8RXtzux8X3iw9X60_l5uvHy_XZpjRc4lTStsWN0JpiAo3hojJCE92AqOsWeEcMbxivgHHDZNfwVtLGSGy6ThpMNMfsuDg5-E4hj5SbU6ONBoZBO_BzVIQLwSQXDcvo67_Qaz8Hl7tTREpGqaT5tTtqpwdQ1nU-BW0WU3XGKomZELTK1Ok_qLy2MFqT_7Wz-f6B4M09QQ96SH30w5yWH3wIkgNogo8xQKemYEcd9opgtWRFHbKiclbUkhUls-bV7WRzO8L2TvEnHBmgByDmkttBuDf6f11_A5ZFyCI</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Zagorodnyaya, E. 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Lithospermum
erythrorhizon L. cell culture. Combined therapy of 30 patients (34-72 years) with erosive ulcerative lichen planus and leukoplakia of the buccal mucosa was carried out. Local application of the new drug led to more rapid pain relief, epithelialization of the inflammatory destructive foci in the buccal mucosa, and reduced the intensity of morphological signs of lesions in the studied patient population.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24319756</pmid><doi>10.1007/s10517-013-2318-7</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2013-12, Vol.156 (2), p.232-235 |
| issn | 0007-4888 1573-8221 |
| language | eng |
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| source | Springer Nature |
| subjects | Adult Aged Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Biomedical and Life Sciences Biomedicine Biopolymers - therapeutic use Cell Biology Drugs, Chinese Herbal - therapeutic use Female Humans Inflammation - drug therapy Internal Medicine Laboratory Medicine Leukoplakia, Oral - drug therapy Lichen Planus, Oral - drug therapy Male Methylcellulose Methylcellulose - analogs & derivatives Methylcellulose - therapeutic use Middle Aged Mouth Mucosa - pathology Naphthoquinones - therapeutic use Oral Ulcer - drug therapy Pathology |
| title | Biopolymeric Film Containing Bioactive Naphthoquinone (Shikonin) in Combined Therapy of Inflammatory Destructive Lesions in the Buccal Mucosa |
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