Brain protein expression changes in WAG/Rij rats, a genetic rat model of absence epilepsy after peripheral lipopolysaccharide treatment

Highlight • The effects of LPS were revealed in a rat model of absence epilepsy on the seizure activity and sleep–wake pattern with EEG and on the brain proteome with proteomics technique.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2014-01, Vol.35, p.86-95
Main Authors: Györffy, Balázs, Kovács, Zsolt, Gulyássy, Péter, Simor, Attila, Völgyi, Katalin, Orbán, Gergely, Baracskay, Péter, Szabó, Zoltán, Janáky, Tamás, Dobolyi, Árpád, Juhász, Gábor, Czurkó, András, Kékesi, Katalin A
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Brain - metabolism
Brain - physiopathology
Brain proteomics
Disease Models, Animal
Electroencephalography
Epilepsy
Epilepsy, Absence - metabolism
Epilepsy, Absence - physiopathology
Inflammation
Inflammation - metabolism
Lipopolysaccharides - toxicity
LPS
NFkB
Proteome
Proteomics
Psychiatry
Rats
Rats, Inbred Strains
Rats, Wistar
Signal Transduction
Sleep–wake cycle
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Description
Summary:Highlight • The effects of LPS were revealed in a rat model of absence epilepsy on the seizure activity and sleep–wake pattern with EEG and on the brain proteome with proteomics technique.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.09.001