Cytochrome P450 4F2 Polymorphism in Patients with Liver Cirrhosis

• Published in: Bulletin of experimental biology and medicine 2013-12, Vol.156 (2), p.181-184
• Main Authors: Vavilin, V. A., Nepomnyashchikh, D. L., Shchepotina, E. G., Karavaeva, Yu. Yu, Makarova, S. I., Vinogradova, E. V., Kudryashov, A. V., Nokhrina, Zh. V., Lyakhovich, V. V.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Arachidonic Acids - metabolism; Biomedical and Life Sciences; Biomedicine; Biophysics and Biochemistry; Cannabinoid Receptor Agonists - metabolism; Care and treatment; Cell Biology; Cytochrome P-450; Cytochrome P-450 Enzyme System - genetics; Cytochrome P450 Family 4; Development and progression; Endocannabinoids - metabolism; Female; Gene Frequency; Genetic aspects; Genetic Predisposition to Disease; Genotype; Humans; Internal Medicine; Laboratory Medicine; Liver cirrhosis; Liver Cirrhosis - genetics; Male; Middle Aged; Pathology; Polymorphism, Single Nucleotide; Polyunsaturated Alkamides - metabolism; Xenobiotics; Young Adult
• ISSN: 0007-4888; 1573-8221
• DOI: 10.1007/s10517-013-2305-z

1297C/T polymorphism of CYP4F2 gene was studied in 108 patients with chronic liver diseases. No significant correlation with predisposition to rapid liver cirrhosis was revealed without consideration for cirrhosis etiology (OR = 0.93, 95% CI = 0.28-2.99, p  = 0.885). In patients with viral cirrhosis, a tendency to association of 1297T allele genotypes with rapid cirrhosis development was found (OR = 6.0, 95% CI = 0.28-382.64, p  = 0.222). At the same time, CYP4F2 1297T allele was associated with mild (Child–Pugh class A-B) cirrhosis (OR = 2.9, p  = 0.044).