Effects of Erythrocyte Microvesicles on the Coagulation Process Stages

We studied the effect of erythrocyte microvesicles on various stages of platelet-free autoplasma coagulation process. The erythrocyte microvesicles not only exhibited procoagulant activity, but also produced a pronounced anticoagulant effect by inhibiting fibrin formation process. The effects of mic...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013-11, Vol.156 (1), p.32-34
Main Authors: Levin, G. Ya, Sukhareva, E. G., Egorikhina, M. N.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood Coagulation
Cell Biology
Cell-Derived Microparticles - physiology
Erythrocytes - physiology
Fibrin
Humans
Internal Medicine
Laboratory Medicine
Pathology
Prothrombin Time
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Summary:We studied the effect of erythrocyte microvesicles on various stages of platelet-free autoplasma coagulation process. The erythrocyte microvesicles not only exhibited procoagulant activity, but also produced a pronounced anticoagulant effect by inhibiting fibrin formation process. The effects of microvesicles isolated from erythrocytes after 24- and 48-hour cell storage on plasma coagulation were different. The hemocoagulation effects of the “light” and “heavy” microvesicles were studied.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-2270-6