Identification of the cell surface receptor for FC3‐2, FC3‐3 and FC3‐6 bacteriophages from Klebsiella pneumoniae

FC3‐2, FC3‐3 and FC3‐6 are different Klebsiella‐specific bacteriophages isolated on Klebsiella pneumoniae strain C3. The common bacteriophage receptor for these phages was shown to be the lipopolysaccharide (LPS), specifically the high‐molecular‐weight polysaccharide fraction (O‐antigen). Mutants re...

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Bibliographic Details
Published in:FEMS microbiology letters 1987-05, Vol.41 (3), p.223-228
Main Authors: Tomás, Juan M., Benedi, Vicente J., Jofre, Juan T.
Format: Article
Language:English
Subjects:
Bacteriophage receptor
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Klebsiella pneumoniae
Lipopolysaccharide
Microbiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
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Summary:FC3‐2, FC3‐3 and FC3‐6 are different Klebsiella‐specific bacteriophages isolated on Klebsiella pneumoniae strain C3. The common bacteriophage receptor for these phages was shown to be the lipopolysaccharide (LPS), specifically the high‐molecular‐weight polysaccharide fraction (O‐antigen). Mutants resistant to these phages were isolated and found to be devoid of lipopolysaccharide O‐antigen by several criteria. We concluded that no other outer membrane (OM) molecules were involved in phage binding. At least 2 different types of lipopolysaccharide‐core mutant were obtained.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1987.tb02201.x