Genotoxic effects of ethylene oxide and their relevance to human cancer

The genetic effects of epoxides, including EtO, and the problems connected with the risk estimation of epoxides have been reviewed by Ehrenberg and Hussain. Several recent reviews have summarized the toxicological and epidemiological data. In this review the authors will up-date the present knowledg...

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Bibliographic Details
Published in:Carcinogenesis (New York) 1986, Vol.7 (8), p.1245-1250
Main Authors: Kolman, Ada, Näslund, Maria, Calleman, Carl Johan
Format: Article
Language:English
Subjects:
Abortion, Spontaneous - chemically induced
Animals
Biological and medical sciences
Chemical mutagenesis
Chromosome Aberrations - drug effects
DNA Repair - drug effects
Ethylene Oxide - adverse effects
Female
Humans
Medical sciences
Mutagens
Mutation
Neoplasms - chemically induced
Nervous System Diseases - chemically induced
Occupational Diseases - chemically induced
Pregnancy
Sister Chromatid Exchange - drug effects
Smoking
Toxicology
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Description
Summary:The genetic effects of epoxides, including EtO, and the problems connected with the risk estimation of epoxides have been reviewed by Ehrenberg and Hussain. Several recent reviews have summarized the toxicological and epidemiological data. In this review the authors will up-date the present knowledge with the emphasis on carcinogenic and genotoxic effects of EtO in experimental animals and occupationally exposed persons.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/7.8.1245