Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma

• Published in: Head & neck 2014-01, Vol.36 (1), p.101-106
• Main Authors: Zeng, Rui-chao, Zhang, Wei, Gao, Er-li, Cheng, Pu, Huang, Guan-li, Zhang, Xiao-hua, Li, Quan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Carcinoma, Papillary - secondary; Carcinoma, Papillary - surgery; central lymph node metastasis; Cervical cancer; Cohort Studies; Confidence Intervals; Female; Humans; lateral lymph node metastasis; Logistic Models; lymph node; Lymph Node Excision - methods; Lymph Node Excision - statistics & numerical data; Lymph Nodes - pathology; Lymph Nodes - surgery; Lymphatic Metastasis; Lymphatic system; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness - pathology; Neoplasm Staging; number of positive central lymph node; Odds Ratio; papillary thyroid microcarcinoma; Predictive Value of Tests; Prognosis; Retrospective Studies; Risk Assessment; Statistics, Nonparametric; Thyroid Neoplasms - pathology; Thyroid Neoplasms - secondary; Thyroid Neoplasms - surgery; Thyroidectomy; Treatment Outcome
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.23270

Background The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). Methods Up to 141 patients with PTMC were divided into 3 groups according to different positive central lymph node classifications as follows: group A, no positive central lymph node; group B, 1 positive central lymph node; and group C, 2 or more positive central lymph nodes. Results Incidence of lateral lymph node metastasis was 30.5% (43 of 141). It was significantly high in group C compared with groups A and B, although there was no significant difference between groups A and B. Number of positive central lymph node ≥2, underlying Hashimoto thyroiditis, and extrathyroidal extension were the independent predictive factors for lateral lymph node metastasis on multivariate analysis. Conclusion Lateral lymph node metastasis was mainly observed in patients with ≥2 positive central lymph nodes, which is an independent predictive factor for lateral lymph node metastasis. Therefore, ≥2 positive central lymph nodes may be valuable in predicting lateral lymph node metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 101–106, 2014