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Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma
Background The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). Methods Up to 141 patients with PTMC were divided into 3 groups accord...
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| Published in: | Head & neck 2014-01, Vol.36 (1), p.101-106 |
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| container_start_page | 101 |
| container_title | Head & neck |
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| creator | Zeng, Rui-chao Zhang, Wei Gao, Er-li Cheng, Pu Huang, Guan-li Zhang, Xiao-hua Li, Quan |
| description | Background
The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).
Methods
Up to 141 patients with PTMC were divided into 3 groups according to different positive central lymph node classifications as follows: group A, no positive central lymph node; group B, 1 positive central lymph node; and group C, 2 or more positive central lymph nodes.
Results
Incidence of lateral lymph node metastasis was 30.5% (43 of 141). It was significantly high in group C compared with groups A and B, although there was no significant difference between groups A and B. Number of positive central lymph node ≥2, underlying Hashimoto thyroiditis, and extrathyroidal extension were the independent predictive factors for lateral lymph node metastasis on multivariate analysis.
Conclusion
Lateral lymph node metastasis was mainly observed in patients with ≥2 positive central lymph nodes, which is an independent predictive factor for lateral lymph node metastasis. Therefore, ≥2 positive central lymph nodes may be valuable in predicting lateral lymph node metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 101–106, 2014 |
| doi_str_mv | 10.1002/hed.23270 |
| format | article |
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The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).
Methods
Up to 141 patients with PTMC were divided into 3 groups according to different positive central lymph node classifications as follows: group A, no positive central lymph node; group B, 1 positive central lymph node; and group C, 2 or more positive central lymph nodes.
Results
Incidence of lateral lymph node metastasis was 30.5% (43 of 141). It was significantly high in group C compared with groups A and B, although there was no significant difference between groups A and B. Number of positive central lymph node ≥2, underlying Hashimoto thyroiditis, and extrathyroidal extension were the independent predictive factors for lateral lymph node metastasis on multivariate analysis.
Conclusion
Lateral lymph node metastasis was mainly observed in patients with ≥2 positive central lymph nodes, which is an independent predictive factor for lateral lymph node metastasis. Therefore, ≥2 positive central lymph nodes may be valuable in predicting lateral lymph node metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 101–106, 2014</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.23270</identifier><identifier>PMID: 23900787</identifier><identifier>CODEN: HEANEE</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Carcinoma, Papillary - secondary ; Carcinoma, Papillary - surgery ; central lymph node metastasis ; Cervical cancer ; Cohort Studies ; Confidence Intervals ; Female ; Humans ; lateral lymph node metastasis ; Logistic Models ; lymph node ; Lymph Node Excision - methods ; Lymph Node Excision - statistics & numerical data ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis ; Lymphatic system ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; number of positive central lymph node ; Odds Ratio ; papillary thyroid microcarcinoma ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Risk Assessment ; Statistics, Nonparametric ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - secondary ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Treatment Outcome</subject><ispartof>Head & neck, 2014-01, Vol.36 (1), p.101-106</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3910-ec0fcc757ebf6dc903488446a77bb68bf261966774671cd1d75c3ff3a8711fb53</citedby><cites>FETCH-LOGICAL-c3910-ec0fcc757ebf6dc903488446a77bb68bf261966774671cd1d75c3ff3a8711fb53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23900787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Rui-chao</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Gao, Er-li</creatorcontrib><creatorcontrib>Cheng, Pu</creatorcontrib><creatorcontrib>Huang, Guan-li</creatorcontrib><creatorcontrib>Zhang, Xiao-hua</creatorcontrib><creatorcontrib>Li, Quan</creatorcontrib><title>Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).
Methods
Up to 141 patients with PTMC were divided into 3 groups according to different positive central lymph node classifications as follows: group A, no positive central lymph node; group B, 1 positive central lymph node; and group C, 2 or more positive central lymph nodes.
Results
Incidence of lateral lymph node metastasis was 30.5% (43 of 141). It was significantly high in group C compared with groups A and B, although there was no significant difference between groups A and B. Number of positive central lymph node ≥2, underlying Hashimoto thyroiditis, and extrathyroidal extension were the independent predictive factors for lateral lymph node metastasis on multivariate analysis.
Conclusion
Lateral lymph node metastasis was mainly observed in patients with ≥2 positive central lymph nodes, which is an independent predictive factor for lateral lymph node metastasis. Therefore, ≥2 positive central lymph nodes may be valuable in predicting lateral lymph node metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 101–106, 2014</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Papillary - secondary</subject><subject>Carcinoma, Papillary - surgery</subject><subject>central lymph node metastasis</subject><subject>Cervical cancer</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Female</subject><subject>Humans</subject><subject>lateral lymph node metastasis</subject><subject>Logistic Models</subject><subject>lymph node</subject><subject>Lymph Node Excision - methods</subject><subject>Lymph Node Excision - statistics & numerical data</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>number of positive central lymph node</subject><subject>Odds Ratio</subject><subject>papillary thyroid microcarcinoma</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Statistics, Nonparametric</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Treatment Outcome</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kUFv1DAQhS0EoqVw4A8gS1zKIe04djzJEdrSIlVFKi0cLcexWZckDnaidv89XrbLAamSJVvW957mzSPkLYMjBlAer2x3VPIS4RnZZ9BgAVzg881b8IIDij3yKqU7AOBSlC_JXskbAKxxnzxcLUNrIw2OGjvOUfe0Xw_Tio6hs3Sws075-ERdiHSKtvNm9uNP2uvZPg37kU568n2v45rOq3UMvqODNzEYHY0fw6BfkxdO98m-ebwPyO3ns5uTi-Ly6_mXk4-XheENg8IacMZghbZ1sjNNTlbXQkiN2Laybl0pWSMlopDITMc6rAx3jusaGXNtxQ_I4dZ3iuH3YtOsBp-MzaONNixJsSwEmXfXZPT9f-hdWOKYp9tQkpWiqjaGH7ZUTpNStE5N0Q85qGKgNnWoXIf6W0dm3z06Lu2Qf3fkbv8ZON4C976366ed1MXZ6c6y2Cp8mu3DP4WOv5REjpX6cXWuxPW3T8BPr9V3_gdus6Rv</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Zeng, Rui-chao</creator><creator>Zhang, Wei</creator><creator>Gao, Er-li</creator><creator>Cheng, Pu</creator><creator>Huang, Guan-li</creator><creator>Zhang, Xiao-hua</creator><creator>Li, Quan</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma</title><author>Zeng, Rui-chao ; Zhang, Wei ; Gao, Er-li ; Cheng, Pu ; Huang, Guan-li ; Zhang, Xiao-hua ; Li, Quan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3910-ec0fcc757ebf6dc903488446a77bb68bf261966774671cd1d75c3ff3a8711fb53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Papillary - secondary</topic><topic>Carcinoma, Papillary - surgery</topic><topic>central lymph node metastasis</topic><topic>Cervical cancer</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Female</topic><topic>Humans</topic><topic>lateral lymph node metastasis</topic><topic>Logistic Models</topic><topic>lymph node</topic><topic>Lymph Node Excision - methods</topic><topic>Lymph Node Excision - statistics & numerical data</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>number of positive central lymph node</topic><topic>Odds Ratio</topic><topic>papillary thyroid microcarcinoma</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Statistics, Nonparametric</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zeng, Rui-chao</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Gao, Er-li</creatorcontrib><creatorcontrib>Cheng, Pu</creatorcontrib><creatorcontrib>Huang, Guan-li</creatorcontrib><creatorcontrib>Zhang, Xiao-hua</creatorcontrib><creatorcontrib>Li, Quan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Rui-chao</au><au>Zhang, Wei</au><au>Gao, Er-li</au><au>Cheng, Pu</au><au>Huang, Guan-li</au><au>Zhang, Xiao-hua</au><au>Li, Quan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2014-01</date><risdate>2014</risdate><volume>36</volume><issue>1</issue><spage>101</spage><epage>106</epage><pages>101-106</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><coden>HEANEE</coden><abstract>Background
The purpose of this study was to present our evaluation of the relationship between the number of positive central lymph nodes and lateral lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC).
Methods
Up to 141 patients with PTMC were divided into 3 groups according to different positive central lymph node classifications as follows: group A, no positive central lymph node; group B, 1 positive central lymph node; and group C, 2 or more positive central lymph nodes.
Results
Incidence of lateral lymph node metastasis was 30.5% (43 of 141). It was significantly high in group C compared with groups A and B, although there was no significant difference between groups A and B. Number of positive central lymph node ≥2, underlying Hashimoto thyroiditis, and extrathyroidal extension were the independent predictive factors for lateral lymph node metastasis on multivariate analysis.
Conclusion
Lateral lymph node metastasis was mainly observed in patients with ≥2 positive central lymph nodes, which is an independent predictive factor for lateral lymph node metastasis. Therefore, ≥2 positive central lymph nodes may be valuable in predicting lateral lymph node metastasis. © 2013 Wiley Periodicals, Inc. Head Neck 36: 101–106, 2014</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23900787</pmid><doi>10.1002/hed.23270</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Carcinoma, Papillary - secondary Carcinoma, Papillary - surgery central lymph node metastasis Cervical cancer Cohort Studies Confidence Intervals Female Humans lateral lymph node metastasis Logistic Models lymph node Lymph Node Excision - methods Lymph Node Excision - statistics & numerical data Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis Lymphatic system Male Middle Aged Multivariate Analysis Neoplasm Invasiveness - pathology Neoplasm Staging number of positive central lymph node Odds Ratio papillary thyroid microcarcinoma Predictive Value of Tests Prognosis Retrospective Studies Risk Assessment Statistics, Nonparametric Thyroid Neoplasms - pathology Thyroid Neoplasms - secondary Thyroid Neoplasms - surgery Thyroidectomy Treatment Outcome |
| title | Number of central lymph node metastasis for predicting lateral lymph node metastasis in papillary thyroid microcarcinoma |
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