YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis

In the diagnosis of malignant mesothelioma (MM) there still is a lack of specific and sensitive screening biomarkers: this study examined the discriminatory power of a panel of serum/plasma biomarkers. The study involved four groups: (a) individuals previously exposed to asbestos with asbestosis; (b...

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Bibliographic Details
Published in:Anticancer research 2013-12, Vol.33 (12), p.5517-5524
Main Authors: Corradi, Massimo, Goldoni, Matteo, Alinovi, Rossella, Tiseo, Marcello, Ampollini, Luca, Bonini, Silvia, Carbognani, Paolo, Casalini, Angelo, Mutti, Antonio
Format: Article
Language:English
Subjects:
Adipokines - blood
Aged
Asbestosis - blood
Biomarkers, Tumor - blood
Case-Control Studies
Chitinase-3-Like Protein 1
Cross-Sectional Studies
Endothelin-1 - blood
Female
GPI-Linked Proteins - blood
Humans
Interleukin-8 - blood
Lectins - blood
Lung Neoplasms - blood
Male
Mesothelioma - blood
Middle Aged
Vascular Endothelial Growth Factor A - blood
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Summary:In the diagnosis of malignant mesothelioma (MM) there still is a lack of specific and sensitive screening biomarkers: this study examined the discriminatory power of a panel of serum/plasma biomarkers. The study involved four groups: (a) individuals previously exposed to asbestos with asbestosis; (b) patients with MM; (c) patients with non-small cell lung cancer; and (d) controls without any evidence of malignancy. The concentrations of mesothelin, chitinase-3-like-1 (YKL-40), vascular endothelial growth factor (VEGF), endothelin-1, interleukin-8 (IL-8) and fibulin-3 in the serum of patients were determined. Patients with MM had significantly higher serum levels of mesothelin (p
ISSN:1791-7530