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YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis

In the diagnosis of malignant mesothelioma (MM) there still is a lack of specific and sensitive screening biomarkers: this study examined the discriminatory power of a panel of serum/plasma biomarkers. The study involved four groups: (a) individuals previously exposed to asbestos with asbestosis; (b...

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Published in:Anticancer research 2013-12, Vol.33 (12), p.5517-5524
Main Authors: Corradi, Massimo, Goldoni, Matteo, Alinovi, Rossella, Tiseo, Marcello, Ampollini, Luca, Bonini, Silvia, Carbognani, Paolo, Casalini, Angelo, Mutti, Antonio
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container_issue 12
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container_title Anticancer research
container_volume 33
creator Corradi, Massimo
Goldoni, Matteo
Alinovi, Rossella
Tiseo, Marcello
Ampollini, Luca
Bonini, Silvia
Carbognani, Paolo
Casalini, Angelo
Mutti, Antonio
description In the diagnosis of malignant mesothelioma (MM) there still is a lack of specific and sensitive screening biomarkers: this study examined the discriminatory power of a panel of serum/plasma biomarkers. The study involved four groups: (a) individuals previously exposed to asbestos with asbestosis; (b) patients with MM; (c) patients with non-small cell lung cancer; and (d) controls without any evidence of malignancy. The concentrations of mesothelin, chitinase-3-like-1 (YKL-40), vascular endothelial growth factor (VEGF), endothelin-1, interleukin-8 (IL-8) and fibulin-3 in the serum of patients were determined. Patients with MM had significantly higher serum levels of mesothelin (p
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subjects Adipokines - blood
Aged
Asbestosis - blood
Biomarkers, Tumor - blood
Case-Control Studies
Chitinase-3-Like Protein 1
Cross-Sectional Studies
Endothelin-1 - blood
Female
GPI-Linked Proteins - blood
Humans
Interleukin-8 - blood
Lectins - blood
Lung Neoplasms - blood
Male
Mesothelioma - blood
Middle Aged
Vascular Endothelial Growth Factor A - blood
title YKL-40 and mesothelin in the blood of patients with malignant mesothelioma, lung cancer and asbestosis
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