Use of biometric, hematologic, and plasma biochemical variables, and histopathology to assess the chronic effects of the herbicide prometryn on Common Carp

• Published in: Veterinary clinical pathology 2013-12, Vol.42 (4), p.508-515
• Main Authors: Velisek, J., Stara, A., Zuskova, E., Svobodova, Z.
• Format: Article
• Language: English
• Subjects: Animals; Behavior, Animal - drug effects; Biomarkers - blood; Biometry; Blood Chemical Analysis - veterinary; Carps - blood; Carps - physiology; Dose-Response Relationship, Drug; Environmental Monitoring; Hematologic Tests - veterinary; Hemoconcentration; herbicide monitoring; Herbicides - blood; Herbicides - pharmacology; Kidney - drug effects; Prometryne - blood; Prometryne - pharmacology; Rivers; Spleen - drug effects; Time Factors; triazine; Water Pollutants, Chemical - blood; Water Pollutants, Chemical - pharmacology; water pollution
• ISSN: 0275-6382; 1939-165X
• DOI: 10.1111/vcp.12081

Background Effects of acute and subchronic exposure of fish to s‐triazine herbicides have been well documented, but data on the effects of prometryn on blood analytes in carp at environmentally realistic concentrations are lacking. Objective The objective of the study was to determine whether biometrics, blood analytes, and histopathology could serve as bioindicators in fish living in waters polluted by triazine. Methods Fish were exposed to prometryn at concentrations of 0.51 (reported concentration in Czech rivers), 8.0, and 80 μg/L for 14, 30, and 60 days. Prior to and during this period, biometrics, blood analytes, and histopathology were evaluated. Results After 60 days' exposure to 8.0 and 80 μg/L of prometryn, spleen weights (P