Do Current Animal Models of Intracerebral Hemorrhage Mirror the Human Pathology?

Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate transl...

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Bibliographic Details
Published in:Translational stroke research 2011-03, Vol.2 (1), p.17-25
Main Authors: Adeoye, Opeolu, Clark, Joseph F., Khatri, Pooja, Wagner, Kenneth R., Zuccarello, Mario, Pyne-Geithman, Gail J.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood products
Cardiology
Edema
Heat shock proteins
Hematoma
Hemorrhage
Hypertension
Ischemia
Neurology
Neurosciences
Neurosurgery
Review
Stroke
Vascular Surgery
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Summary:Although intracerebral hemorrhage (ICH) has no proven treatment, well-designed studies using animal models of ICH may lead to the development of novel therapies. We briefly review current animal models of ICH. Furthermore, we discuss how these models may be utilized and targeted to facilitate translation of preclinical findings to the clinical arena.
ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-010-0037-1