Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population

Background Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD). Methods A total of 13...

Full description

Saved in:
Bibliographic Details
Published in:Liver international 2014-01, Vol.34 (1), p.102-109
Main Authors: Chon, Young Eun, Jung, Kyu Sik, Kim, Seung Up, Park, Jun Yong, Park, Young Nyun, Kim, Do Young, Ahn, Sang Hoon, Chon, Chae Yoon, Lee, Hye Won, Park, Yehyun, Han, Kwang-Hyub
Format: Article
Language:English
Subjects:
Adolescent
Adult
Area Under Curve
Asian Continental Ancestry Group
Biopsy
Chronic Disease
Chronic liver disease
controlled attenuation parameter
Elasticity Imaging Techniques - methods
fatty liver
Fatty Liver - diagnostic imaging
Fatty Liver - ethnology
Female
Humans
Linear Models
Liver Diseases - diagnostic imaging
Liver Diseases - ethnology
Male
Middle Aged
Multivariate Analysis
non-alcoholic fatty liver disease
non-alcoholic steatohepatitis
Predictive Value of Tests
Prospective Studies
Republic of Korea
Risk Factors
ROC Curve
Severity of Illness Index
steatosis
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD). Methods A total of 135 patients with CLD who underwent liver biopsy and CAP were consecutively enrolled in this prospective study. The performance of CAP for detection of hepatic steatosis compared with liver biopsy was calculated using area under receiver operating characteristics curves (AUROC). Steatosis was categorized into S0 (66% of hepatocytes). Results Male gender predominated (n = 87, 64%) and the median age was 51 years. The aetiologies of CLD included non‐alcoholic fatty liver disease (n = 56, 41.5%) and chronic viral hepatitis because of hepatitis B (n = 47, 34.8%) and C (n = 12, 8.9%). Steatosis repartition was: S0 31.1% (n = 42), S1 43.7% (n = 59), S2 18.5% (n = 25) and S3 6.7% (n = 9) respectively. In the multivariate analysis, steatosis grade and body mass index were independently associated with CAP (all P 
ISSN:1478-3223
1478-3231
DOI:10.1111/liv.12282