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Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population
Background Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD). Methods A total of 13...
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| Published in: | Liver international 2014-01, Vol.34 (1), p.102-109 |
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| container_issue | 1 |
| container_start_page | 102 |
| container_title | Liver international |
| container_volume | 34 |
| creator | Chon, Young Eun Jung, Kyu Sik Kim, Seung Up Park, Jun Yong Park, Young Nyun Kim, Do Young Ahn, Sang Hoon Chon, Chae Yoon Lee, Hye Won Park, Yehyun Han, Kwang-Hyub |
| description | Background
Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD).
Methods
A total of 135 patients with CLD who underwent liver biopsy and CAP were consecutively enrolled in this prospective study. The performance of CAP for detection of hepatic steatosis compared with liver biopsy was calculated using area under receiver operating characteristics curves (AUROC). Steatosis was categorized into S0 (66% of hepatocytes).
Results
Male gender predominated (n = 87, 64%) and the median age was 51 years. The aetiologies of CLD included non‐alcoholic fatty liver disease (n = 56, 41.5%) and chronic viral hepatitis because of hepatitis B (n = 47, 34.8%) and C (n = 12, 8.9%). Steatosis repartition was: S0 31.1% (n = 42), S1 43.7% (n = 59), S2 18.5% (n = 25) and S3 6.7% (n = 9) respectively. In the multivariate analysis, steatosis grade and body mass index were independently associated with CAP (all P |
| doi_str_mv | 10.1111/liv.12282 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1467067964</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1467067964</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3632-6adabbdbf76eb6330120f9b8006be4b06acab6ca35a434bce9086369947a3ad33</originalsourceid><addsrcrecordid>eNp1kcFy0zAQQDUMDC0tB36A0bE9uJUsRba5dTIkdEgLZQocNSt7PRE4livJLfmffmiVpM0NXaSV3r7Z1RLygbMzntZ5Z-_PeJ6X-StyyGVRZiIX_PX-nIsD8i6EP4zxqprwt-QglyzRXB6Sx6nro3ddhw2FGLEfIVrX0wE8rDCipyfTi--ntHWeNimut6-upUscElnTEBGiCzZQu8mKFvsY6IONS1ovvesTkspLnsYGhIDhEwU6eBeGjesek2Bs1hsj0B62N1-dR0gyN4zdtppj8qaFLuD75_2I_Jx9vp1-yRbf5pfTi0VWCyXyTEEDxjSmLRQaJQTjOWsrUzKmDErDFNRgVA1iAlJIU2PFSiVUVckCBDRCHJGTnTfVdzdiiHplQ41dBz26MWguVcFUUSmZ0NMdWqdWgsdWD96uwK81Z3ozFJ261tuhJPbjs3Y0K2z25MsUEnC-Ax5sh-v_m_Ti8teLMttl2PT___YZ4P9qVYhion9fz_Xsx6zktzdzfSWeAHIvqVU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1467067964</pqid></control><display><type>article</type><title>Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Chon, Young Eun ; Jung, Kyu Sik ; Kim, Seung Up ; Park, Jun Yong ; Park, Young Nyun ; Kim, Do Young ; Ahn, Sang Hoon ; Chon, Chae Yoon ; Lee, Hye Won ; Park, Yehyun ; Han, Kwang-Hyub</creator><creatorcontrib>Chon, Young Eun ; Jung, Kyu Sik ; Kim, Seung Up ; Park, Jun Yong ; Park, Young Nyun ; Kim, Do Young ; Ahn, Sang Hoon ; Chon, Chae Yoon ; Lee, Hye Won ; Park, Yehyun ; Han, Kwang-Hyub</creatorcontrib><description>Background
Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD).
Methods
A total of 135 patients with CLD who underwent liver biopsy and CAP were consecutively enrolled in this prospective study. The performance of CAP for detection of hepatic steatosis compared with liver biopsy was calculated using area under receiver operating characteristics curves (AUROC). Steatosis was categorized into S0 (<5%), S1 (5–33%), S2 (34–66%) and S3 (>66% of hepatocytes).
Results
Male gender predominated (n = 87, 64%) and the median age was 51 years. The aetiologies of CLD included non‐alcoholic fatty liver disease (n = 56, 41.5%) and chronic viral hepatitis because of hepatitis B (n = 47, 34.8%) and C (n = 12, 8.9%). Steatosis repartition was: S0 31.1% (n = 42), S1 43.7% (n = 59), S2 18.5% (n = 25) and S3 6.7% (n = 9) respectively. In the multivariate analysis, steatosis grade and body mass index were independently associated with CAP (all P < 0.001), whereas fibrosis stage and activity grade were not. The AUROCs of CAP were 0.885 for ≥S1 (sensitivity 73.1%, specificity 95.2%), 0.894 for ≥S2 (sensitivity 82.4%, specificity 86.1%) and 0.800 for S3 (sensitivity 77.8%, specificity 84.1%). The optimal cut‐off CAP values that maximized the Youden index were 250 dB/m (≥S1), 299 dB/m (≥S2), and 327 dB/m (=S3) respectively.
Conclusions
Our data showed that CAP had high diagnostic accuracy for detecting hepatic steatosis in patients with CLD and suggested that CAP is also applicable for Asian patients.</description><identifier>ISSN: 1478-3223</identifier><identifier>EISSN: 1478-3231</identifier><identifier>DOI: 10.1111/liv.12282</identifier><identifier>PMID: 24028214</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Area Under Curve ; Asian Continental Ancestry Group ; Biopsy ; Chronic Disease ; Chronic liver disease ; controlled attenuation parameter ; Elasticity Imaging Techniques - methods ; fatty liver ; Fatty Liver - diagnostic imaging ; Fatty Liver - ethnology ; Female ; Humans ; Linear Models ; Liver Diseases - diagnostic imaging ; Liver Diseases - ethnology ; Male ; Middle Aged ; Multivariate Analysis ; non-alcoholic fatty liver disease ; non-alcoholic steatohepatitis ; Predictive Value of Tests ; Prospective Studies ; Republic of Korea ; Risk Factors ; ROC Curve ; Severity of Illness Index ; steatosis ; Young Adult</subject><ispartof>Liver international, 2014-01, Vol.34 (1), p.102-109</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3632-6adabbdbf76eb6330120f9b8006be4b06acab6ca35a434bce9086369947a3ad33</citedby><cites>FETCH-LOGICAL-c3632-6adabbdbf76eb6330120f9b8006be4b06acab6ca35a434bce9086369947a3ad33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24028214$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chon, Young Eun</creatorcontrib><creatorcontrib>Jung, Kyu Sik</creatorcontrib><creatorcontrib>Kim, Seung Up</creatorcontrib><creatorcontrib>Park, Jun Yong</creatorcontrib><creatorcontrib>Park, Young Nyun</creatorcontrib><creatorcontrib>Kim, Do Young</creatorcontrib><creatorcontrib>Ahn, Sang Hoon</creatorcontrib><creatorcontrib>Chon, Chae Yoon</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Park, Yehyun</creatorcontrib><creatorcontrib>Han, Kwang-Hyub</creatorcontrib><title>Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population</title><title>Liver international</title><addtitle>Liver Int</addtitle><description>Background
Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD).
Methods
A total of 135 patients with CLD who underwent liver biopsy and CAP were consecutively enrolled in this prospective study. The performance of CAP for detection of hepatic steatosis compared with liver biopsy was calculated using area under receiver operating characteristics curves (AUROC). Steatosis was categorized into S0 (<5%), S1 (5–33%), S2 (34–66%) and S3 (>66% of hepatocytes).
Results
Male gender predominated (n = 87, 64%) and the median age was 51 years. The aetiologies of CLD included non‐alcoholic fatty liver disease (n = 56, 41.5%) and chronic viral hepatitis because of hepatitis B (n = 47, 34.8%) and C (n = 12, 8.9%). Steatosis repartition was: S0 31.1% (n = 42), S1 43.7% (n = 59), S2 18.5% (n = 25) and S3 6.7% (n = 9) respectively. In the multivariate analysis, steatosis grade and body mass index were independently associated with CAP (all P < 0.001), whereas fibrosis stage and activity grade were not. The AUROCs of CAP were 0.885 for ≥S1 (sensitivity 73.1%, specificity 95.2%), 0.894 for ≥S2 (sensitivity 82.4%, specificity 86.1%) and 0.800 for S3 (sensitivity 77.8%, specificity 84.1%). The optimal cut‐off CAP values that maximized the Youden index were 250 dB/m (≥S1), 299 dB/m (≥S2), and 327 dB/m (=S3) respectively.
Conclusions
Our data showed that CAP had high diagnostic accuracy for detecting hepatic steatosis in patients with CLD and suggested that CAP is also applicable for Asian patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Area Under Curve</subject><subject>Asian Continental Ancestry Group</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Chronic liver disease</subject><subject>controlled attenuation parameter</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>fatty liver</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Fatty Liver - ethnology</subject><subject>Female</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Liver Diseases - diagnostic imaging</subject><subject>Liver Diseases - ethnology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>non-alcoholic fatty liver disease</subject><subject>non-alcoholic steatohepatitis</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Republic of Korea</subject><subject>Risk Factors</subject><subject>ROC Curve</subject><subject>Severity of Illness Index</subject><subject>steatosis</subject><subject>Young Adult</subject><issn>1478-3223</issn><issn>1478-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kcFy0zAQQDUMDC0tB36A0bE9uJUsRba5dTIkdEgLZQocNSt7PRE4livJLfmffmiVpM0NXaSV3r7Z1RLygbMzntZ5Z-_PeJ6X-StyyGVRZiIX_PX-nIsD8i6EP4zxqprwt-QglyzRXB6Sx6nro3ddhw2FGLEfIVrX0wE8rDCipyfTi--ntHWeNimut6-upUscElnTEBGiCzZQu8mKFvsY6IONS1ovvesTkspLnsYGhIDhEwU6eBeGjesek2Bs1hsj0B62N1-dR0gyN4zdtppj8qaFLuD75_2I_Jx9vp1-yRbf5pfTi0VWCyXyTEEDxjSmLRQaJQTjOWsrUzKmDErDFNRgVA1iAlJIU2PFSiVUVckCBDRCHJGTnTfVdzdiiHplQ41dBz26MWguVcFUUSmZ0NMdWqdWgsdWD96uwK81Z3ozFJ261tuhJPbjs3Y0K2z25MsUEnC-Ax5sh-v_m_Ti8teLMttl2PT___YZ4P9qVYhion9fz_Xsx6zktzdzfSWeAHIvqVU</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Chon, Young Eun</creator><creator>Jung, Kyu Sik</creator><creator>Kim, Seung Up</creator><creator>Park, Jun Yong</creator><creator>Park, Young Nyun</creator><creator>Kim, Do Young</creator><creator>Ahn, Sang Hoon</creator><creator>Chon, Chae Yoon</creator><creator>Lee, Hye Won</creator><creator>Park, Yehyun</creator><creator>Han, Kwang-Hyub</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201401</creationdate><title>Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population</title><author>Chon, Young Eun ; Jung, Kyu Sik ; Kim, Seung Up ; Park, Jun Yong ; Park, Young Nyun ; Kim, Do Young ; Ahn, Sang Hoon ; Chon, Chae Yoon ; Lee, Hye Won ; Park, Yehyun ; Han, Kwang-Hyub</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3632-6adabbdbf76eb6330120f9b8006be4b06acab6ca35a434bce9086369947a3ad33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Area Under Curve</topic><topic>Asian Continental Ancestry Group</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Chronic liver disease</topic><topic>controlled attenuation parameter</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>fatty liver</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Fatty Liver - ethnology</topic><topic>Female</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Liver Diseases - diagnostic imaging</topic><topic>Liver Diseases - ethnology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>non-alcoholic fatty liver disease</topic><topic>non-alcoholic steatohepatitis</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Republic of Korea</topic><topic>Risk Factors</topic><topic>ROC Curve</topic><topic>Severity of Illness Index</topic><topic>steatosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chon, Young Eun</creatorcontrib><creatorcontrib>Jung, Kyu Sik</creatorcontrib><creatorcontrib>Kim, Seung Up</creatorcontrib><creatorcontrib>Park, Jun Yong</creatorcontrib><creatorcontrib>Park, Young Nyun</creatorcontrib><creatorcontrib>Kim, Do Young</creatorcontrib><creatorcontrib>Ahn, Sang Hoon</creatorcontrib><creatorcontrib>Chon, Chae Yoon</creatorcontrib><creatorcontrib>Lee, Hye Won</creatorcontrib><creatorcontrib>Park, Yehyun</creatorcontrib><creatorcontrib>Han, Kwang-Hyub</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Liver international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chon, Young Eun</au><au>Jung, Kyu Sik</au><au>Kim, Seung Up</au><au>Park, Jun Yong</au><au>Park, Young Nyun</au><au>Kim, Do Young</au><au>Ahn, Sang Hoon</au><au>Chon, Chae Yoon</au><au>Lee, Hye Won</au><au>Park, Yehyun</au><au>Han, Kwang-Hyub</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population</atitle><jtitle>Liver international</jtitle><addtitle>Liver Int</addtitle><date>2014-01</date><risdate>2014</risdate><volume>34</volume><issue>1</issue><spage>102</spage><epage>109</epage><pages>102-109</pages><issn>1478-3223</issn><eissn>1478-3231</eissn><abstract>Background
Controlled attenuation parameter (CAP) is a non‐invasive method of measuring hepatic steatosis using a process based on transient elastography. We investigated the diagnostic accuracy of CAP in detecting hepatic steatosis in patients with chronic liver disease (CLD).
Methods
A total of 135 patients with CLD who underwent liver biopsy and CAP were consecutively enrolled in this prospective study. The performance of CAP for detection of hepatic steatosis compared with liver biopsy was calculated using area under receiver operating characteristics curves (AUROC). Steatosis was categorized into S0 (<5%), S1 (5–33%), S2 (34–66%) and S3 (>66% of hepatocytes).
Results
Male gender predominated (n = 87, 64%) and the median age was 51 years. The aetiologies of CLD included non‐alcoholic fatty liver disease (n = 56, 41.5%) and chronic viral hepatitis because of hepatitis B (n = 47, 34.8%) and C (n = 12, 8.9%). Steatosis repartition was: S0 31.1% (n = 42), S1 43.7% (n = 59), S2 18.5% (n = 25) and S3 6.7% (n = 9) respectively. In the multivariate analysis, steatosis grade and body mass index were independently associated with CAP (all P < 0.001), whereas fibrosis stage and activity grade were not. The AUROCs of CAP were 0.885 for ≥S1 (sensitivity 73.1%, specificity 95.2%), 0.894 for ≥S2 (sensitivity 82.4%, specificity 86.1%) and 0.800 for S3 (sensitivity 77.8%, specificity 84.1%). The optimal cut‐off CAP values that maximized the Youden index were 250 dB/m (≥S1), 299 dB/m (≥S2), and 327 dB/m (=S3) respectively.
Conclusions
Our data showed that CAP had high diagnostic accuracy for detecting hepatic steatosis in patients with CLD and suggested that CAP is also applicable for Asian patients.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24028214</pmid><doi>10.1111/liv.12282</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Area Under Curve Asian Continental Ancestry Group Biopsy Chronic Disease Chronic liver disease controlled attenuation parameter Elasticity Imaging Techniques - methods fatty liver Fatty Liver - diagnostic imaging Fatty Liver - ethnology Female Humans Linear Models Liver Diseases - diagnostic imaging Liver Diseases - ethnology Male Middle Aged Multivariate Analysis non-alcoholic fatty liver disease non-alcoholic steatohepatitis Predictive Value of Tests Prospective Studies Republic of Korea Risk Factors ROC Curve Severity of Illness Index steatosis Young Adult |
| title | Controlled attenuation parameter (CAP) for detection of hepatic steatosis in patients with chronic liver diseases: a prospective study of a native Korean population |
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