A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

• Published in: Vaccine 2013-10, Vol.31 (42), p.4874-4880
• Main Authors: Frey, Sharon E, Lottenbach, Kathleen R, Hill, Heather, Blevins, Tamara P, Yu, Yinyi, Zhang, Ying, Brenneman, Karen E, Kelly-Aehle, Sandra M, McDonald, Caitlin, Jansen, Angela, Curtiss, Roy
• Format: Article
• Language: English
• Subjects: Administration, Oral; Adult; Allergy and Immunology; Animals; Antibodies, Bacterial - blood; Applied microbiology; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Bacteriology; Biological and medical sciences; Drug Carriers; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - pathology; ELISA; ELISPOT; Enzyme-Linked Immunosorbent Assay; Enzyme-Linked Immunospot Assay; Female; Fundamental and applied biological sciences. Psychology; Humans; Immunoglobulin A - blood; Immunoglobulin G - blood; Male; Microbiology; Miscellaneous; Pneumococcal surface protein A; Pneumococcal Vaccines - administration & dosage; Pneumococcal Vaccines - adverse effects; Pneumococcal Vaccines - genetics; Pneumococcal Vaccines - immunology; Salmonella enterica; Salmonella typhi; Salmonella typhi - genetics; Salmonella Typhi vaccine vector; Salmonella typhimurium; Streptococcus pneumoniae; Streptococcus pneumoniae - genetics; Streptococcus pneumoniae - immunology; Typhoid-Paratyphoid Vaccines - administration & dosage; Typhoid-Paratyphoid Vaccines - adverse effects; Typhoid-Paratyphoid Vaccines - genetics; Typhoid-Paratyphoid Vaccines - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - adverse effects; Vaccines, Attenuated - genetics; Vaccines, Attenuated - immunology; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - adverse effects; Vaccines, Synthetic - genetics; Vaccines, Synthetic - immunology; Young Adult
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.07.049

Highlights • Three live attenuated, recombinant S . Typhi vectors were evaluated as oral vaccines. • The target antigen was pneumococcal surface protein A (PspA) antigen. • IgG and IgA responses were measured using ELISA and ELISPOT assay.