Influence of Food Restriction Combined with Voluntary Running on Bone Morphology and Strength in Male Rats

Athletes, in particular endurance athletes and dancers, are chronically exposed to a state of low energy availability due to insufficient dietary energy intake and massive exercise energy expenditure. Low energy availability sometimes causes bone fragility, thereby increasing the risk of bone disord...

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Bibliographic Details
Published in:Calcified tissue international 2013-12, Vol.93 (6), p.540-548
Main Authors: Hattori, Satoshi, Park, Jong-Hoon, Agata, Umon, Akimoto, Takayuki, Oda, Masaya, Higano, Michito, Aikawa, Yuki, Nabekura, Yoshiharu, Yamato, Hideyuki, Ezawa, Ikuko, Omi, Naomi
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biomedical and Life Sciences
Body Weight
Bone (trabecular)
Bone and Bones - metabolism
Bone and Bones - pathology
Bone Density
Bone Remodeling
Cell Biology
Diet
Endocrinology
Energy Metabolism
Femur - pathology
Food Deprivation
Life Sciences
Male
Males
Morphology
Original Research
Orthopedics
Physical Conditioning, Animal
Rats
Rats, Sprague-Dawley
Rodents
Running
Tibia - pathology
Time Factors
X-Ray Microtomography
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Summary:Athletes, in particular endurance athletes and dancers, are chronically exposed to a state of low energy availability due to insufficient dietary energy intake and massive exercise energy expenditure. Low energy availability sometimes causes bone fragility, thereby increasing the risk of bone disorders. Although the decrease in energy availability shows no sexual dimorphism, epidemiological studies have reported that bone disorders are less frequent in male athletes than in female athletes. We hypothesized that bone tissue was not affected by low energy availability in males. The purpose of this study was to examine the influence of food restriction combined with voluntary running training on bone morphology and strength in adult male rats. Fourteen-week-old male Sprague–Dawley rats were divided randomly into four groups: control (C) group, food restriction (R) group, exercise (Ex) group, and food restriction plus exercise (REx) group. For the R and REx groups, 30 % food restriction was carried out in comparison with the C group. Bone strength, bone mineral density (BMD), bone architecture, and bone turnover rate were measured after a 13-week experimental period. Bone strength was not significantly lower in the REx group compared with the C group. BMD and trabecular bone volume showed no difference among groups. These findings indicate that bone morphology and strength were little affected by food restriction combined with exercise training in adult male rats.
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-013-9787-6