Maternal age and adverse pregnancy outcome: a cohort study

ABSTRACT Objective To examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. Methods This was a retrospective study in women with singleton pregnancies attending the first...

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Bibliographic Details
Published in:Ultrasound in obstetrics & gynecology 2013-12, Vol.42 (6), p.634-643
Main Authors: Khalil, A., Syngelaki, A., Maiz, N., Zinevich, Y., Nicolaides, K. H.
Format: Article
Language:English
Subjects:
Abortion
Abortion, Spontaneous - epidemiology
Adult
Birth weight
Cesarean section
Cesarean Section - statistics & numerical data
Cohort Studies
Diabetes, Gestational - epidemiology
Female
Fetal Macrosomia - epidemiology
gestational diabetes
Humans
Hypertension
Infant, Newborn
Infant, Small for Gestational Age
Logistic Models
Maternal Age
Miscarriage
Multivariate Analysis
Obstetrics
Pre-Eclampsia - epidemiology
Preeclampsia
Pregnancy
pregnancy complications
Pregnancy Complications - epidemiology
Premature Birth - epidemiology
preterm delivery
pre‐eclampsia
Retrospective Studies
Smoking - epidemiology
stillbirth
Stillbirth - epidemiology
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Summary:ABSTRACT Objective To examine the association between maternal age and a wide range of adverse pregnancy outcomes after adjustment for confounding factors in obstetric history and maternal characteristics. Methods This was a retrospective study in women with singleton pregnancies attending the first routine hospital visit at 11 + 0 to 13 + 6 weeks' gestation. Data on maternal characteristics, and medical and obstetric history were collected and pregnancy outcomes ascertained. Maternal age was studied, both as a continuous and as a categorical variable. Regression analysis was performed to examine the association between maternal age and adverse pregnancy outcome including pre‐eclampsia, gestational hypertension, gestational diabetes mellitus (GDM), preterm delivery, small‐for‐gestational age (SGA) neonate, large‐for‐gestational age (LGA) neonate, miscarriage, stillbirth and elective and emergency Cesarean section. Results The study population included 76 158 singleton pregnancies with a live fetus at 11 + 0 to 13 + 6 weeks. After adjusting for potential maternal and pregnancy confounding variables, advanced maternal age (defined as ≥ 40 years) was associated with increased risk of miscarriage (odds ratio (OR), 2.32 (95% CI, 1.83–2.93); P 
ISSN:0960-7692
1469-0705
DOI:10.1002/uog.12494