Microbiota Keep the Intestinal Clock Ticking

Daily metabolic patterns are regulated in a circadian manner often via the hypothalamic axis. Mukherji et al. now report a surprising role for commensal bacteria in the circadian regulation of glucocorticoid production by intestinal epithelial cells.

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Bibliographic Details
Published in:Cell 2013-05, Vol.153 (4), p.741-743
Main Authors: Henao-Mejia, Jorge, Strowig, Till, Flavell, Richard A.
Format: Article
Language:English
Subjects:
bacteria
circadian rhythm
CLOCK protein
commensalism
glucocorticoids
intestinal mucosa
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Description
Summary:Daily metabolic patterns are regulated in a circadian manner often via the hypothalamic axis. Mukherji et al. now report a surprising role for commensal bacteria in the circadian regulation of glucocorticoid production by intestinal epithelial cells.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.04.043