Synthesis of derivatives of pyrazolo[1,5-a]pyrimidines and imidazo[1,5-a]pyrimidines proceeding from alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates

Methods were developed of the synthesis of alkyl 2-hydroxy-2-fluoroalkyl-4-phenyl-1,2,3,4—tetrahydroimidazo-[1,5- a ]pyrimidine-3-carboxylates and alkyl-5-hydroxy-2,7-diphenyl-5-fluoroalkyl-4,5,6,7-tetrahydropyrazolo[1,5- a ]pyrimidine-6-carboxylates by regioselective [3+3]-cycloaddition of 5-aminoi...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2009-02, Vol.45 (2), p.242-247
Main Authors: Pryadeina, M. V., Burgart, Ya. V., Saloutin, V. I., Slepukhin, P. A., Sadchikova, E. V., Ulomskii, E. N.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Organic Chemistry
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Summary:Methods were developed of the synthesis of alkyl 2-hydroxy-2-fluoroalkyl-4-phenyl-1,2,3,4—tetrahydroimidazo-[1,5- a ]pyrimidine-3-carboxylates and alkyl-5-hydroxy-2,7-diphenyl-5-fluoroalkyl-4,5,6,7-tetrahydropyrazolo[1,5- a ]pyrimidine-6-carboxylates by regioselective [3+3]-cycloaddition of 5-aminoimidazole or 5-aminopyrazole to alkyl 2-benzylidene-3-oxo-3-fluoroalkylpropionates at the fluoroacylvinyl fragment.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428009020158