Microwave promoted C6-alkylation of purines through SNAr-based reaction of 6-chloropurines with 3-alkyl-acetylacetone

C6-Alkylated purine analogues were obtained in good to excellent isolated yields by SNAr reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone. 3-Alkyl-acetylacetones were employed as alkylating agents and C6-alkylated purines were obtained highly selectively within short reaction time u...

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Published in:Organic & biomolecular chemistry 2011-01, Vol.9 (7), p.2065-2068
Main Authors: Guo, Hai-Ming, Zhang, Yu, Niu, Hong-Ying, Wang, Dong-Chao, Chu, Zhi-Liang, Qu, Gui-Rong
Format: Article
Language:English
Subjects:
Alkylating agents
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Summary:C6-Alkylated purine analogues were obtained in good to excellent isolated yields by SNAr reaction of 6-chloropurine derivatives with 3-alkyl-acetylacetone. 3-Alkyl-acetylacetones were employed as alkylating agents and C6-alkylated purines were obtained highly selectively within short reaction time under microwave irradiation conditions. This work is complementary to the classical coupling reactions for the synthesis of C6-alkylated purine analogues.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob01213k