One-step synthesis of chromene-3-carboxamide, bis-chromene, chromeno[3,4-c]pyridine and bischromeno[3,4-c]pyridine derivatives for antimicrobial evaluation

Cyanoacetamide derivatives were reacted with salicylaldehyde under different conditions afforded chromenes and coumarin derivatives respectively. A number of chromeno[3,4-c]pyridine derivatives were prepared from the reaction of N-cyclohexyl-2-imino-2H-chromene-3-carboxamide with malononitrile and/o...

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Bibliographic Details
Published in:Journal of chemical research 2010-08, Vol.34 (8), p.465-469
Main Authors: Helal, Mohamed H, El-Hag, Gameel A M, Ali, Ahmed A, Ammar, Yousry A
Format: Article
Language:English
Online Access:Get full text
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Summary:Cyanoacetamide derivatives were reacted with salicylaldehyde under different conditions afforded chromenes and coumarin derivatives respectively. A number of chromeno[3,4-c]pyridine derivatives were prepared from the reaction of N-cyclohexyl-2-imino-2H-chromene-3-carboxamide with malononitrile and/or cynaothiocatemaide. Bischromeno[3,4-c]pyridine derivatives were prepared from the reaction of N,N'-(ethane-1,2-diyl)bis(2-imino-2H-chromene-3-carboxamide) with malononitrile and/or N-alkyl-2-cyanoacetamide derivative with 2-iminochroemen derivative, respectively. Some of these compounds were screened for their antimicrobial activities.
ISSN:1747-5198
2047-6507
DOI:10.3184/030823410X12812852410870