Iothalamate versus estimated GFR in a Hispanic-dominant pediatric renal transplant population

Background Accurate knowledge of glomerular filtration rate (GFR) is essential to the practice of nephrology. Routine surveillance of GFR is most commonly executed using estimated GFR (eGFR) calculations, most often from serum creatinine measurements. However, cystatin C-based equations have demonst...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2013-12, Vol.28 (12), p.2369-2376
Main Authors: Papez, Karen E., Barletta, Gina-Marie, Hsieh, Stephanie, Joseph, Mark, Morgenstern, Bruce Z.
Format: Article
Language:English
Subjects:
Adolescent
Arizona - epidemiology
Biomarkers - blood
Child
Children
Creatinine
Creatinine - blood
Cystatin C - blood
Diseases
Ethnicity
Female
Glomerular Filtration Rate
Hispanic Americans
Hispanic people
Humans
Iothalamic Acid
Kidney - physiopathology
Kidney Transplantation
Kidney transplants
Kidneys
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Models, Biological
Nephrology
Original Article
Patients
Pediatrics
Predictive Value of Tests
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - ethnology
Renal Insufficiency, Chronic - physiopathology
Renal Insufficiency, Chronic - surgery
Reproducibility of Results
Retrospective Studies
Surveillance
Time Factors
Transplantation
Treatment Outcome
Urology
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Description
Summary:Background Accurate knowledge of glomerular filtration rate (GFR) is essential to the practice of nephrology. Routine surveillance of GFR is most commonly executed using estimated GFR (eGFR) calculations, most often from serum creatinine measurements. However, cystatin C-based equations have demonstrated earlier sensitivity to decline in renal function. The literature regarding eGFR from cystatin C has few references that include transplant recipients. Additionally, for most of the published eGFR equations, patients of Hispanic ethnicity have not been enrolled in sufficient numbers. Methods The applicability of several eGFR equations to the pediatric kidney transplant population at our center were compared in the context of determining whether Hispanic ethnicity was associated with equation performance. Results Updated Schwartz, CKiD, and Zappitelli eGFR estimation equations demonstrated the highest correlations. Conclusions The authors recommend further prospective investigations to validate and identify factors contributing to these findings.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-013-2556-y