Calmodulin activity in yeast and mycelial phases of Ceratocystis ulmi

The yeast and mycelial phases of Ceratocystis ulmi contained roughly equivalent levels of calmodulin activity as determined by their ability to stimulate calmodulin‐deficient bovine brain cAMP phosphodiesterase. This stimulation was calcium‐dependent and could be inhibited by either dibucaine or tri...

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Bibliographic Details
Published in:FEMS microbiology letters 1986, Vol.37 (3), p.313-316
Main Authors: Muthukumar, G, Luby, M.T, Nickerson, K.W
Format: Article
Language:English
Subjects:
Biological and medical sciences
calcium
calcium-binding proteins
calmodulin
Ceratocystis ulmi
cyclic nucleotide phosphodiesterase
dimorphism
Fundamental and applied biological sciences. Psychology
Growth, nutrition, metabolism, transports, enzymes. Molecular biology
Microbiology
mycelium
Mycology
trifluoperazine
yeasts
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Summary:The yeast and mycelial phases of Ceratocystis ulmi contained roughly equivalent levels of calmodulin activity as determined by their ability to stimulate calmodulin‐deficient bovine brain cAMP phosphodiesterase. This stimulation was calcium‐dependent and could be inhibited by either dibucaine or trifluoperazine. Also, the concentration of dibucaine necessary to achieve the mycelium‐to‐yeast morphological conversion was found to be 3‐fold greater in the presence of exogenous calcium. A model is presented in which only 30% of the cellular calmodulin need be complexed with calcium ions for mycelial development.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1986.tb01815.x