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Prognostic significance of NANOG and KLF4 for breast cancer
Background Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients. Methods...
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| Published in: | Breast cancer (Tokyo, Japan) Japan), 2014, Vol.21 (1), p.96-101 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c435t-12336741c0147511e6b81edf5cf9338bb6ce6447cd000da816fc196362e401bf3 |
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| cites | cdi_FETCH-LOGICAL-c435t-12336741c0147511e6b81edf5cf9338bb6ce6447cd000da816fc196362e401bf3 |
| container_end_page | 101 |
| container_issue | 1 |
| container_start_page | 96 |
| container_title | Breast cancer (Tokyo, Japan) |
| container_volume | 21 |
| creator | Nagata, Takuya Shimada, Yutaka Sekine, Shinichi Hori, Ryota Matsui, Koshi Okumura, Tomoyuki Sawada, Shigeaki Fukuoka, Junya Tsukada, Kazuhiro |
| description | Background
Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
Methods
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
Results
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (
P
= 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (
P
= 0.014).
Conclusions
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes. |
| doi_str_mv | 10.1007/s12282-012-0357-y |
| format | article |
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Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
Methods
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
Results
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (
P
= 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (
P
= 0.014).
Conclusions
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.</description><identifier>ISSN: 1340-6868</identifier><identifier>EISSN: 1880-4233</identifier><identifier>DOI: 10.1007/s12282-012-0357-y</identifier><identifier>PMID: 22528804</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - metabolism ; Breast Neoplasms - mortality ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Cancer patients ; Cancer Research ; Disease-Free Survival ; DNA microarrays ; Female ; Homeodomain Proteins - metabolism ; Humans ; Immunohistochemistry ; Kruppel-Like Transcription Factors - metabolism ; Medicine ; Medicine & Public Health ; Metastasis ; Middle Aged ; Nanog Homeobox Protein ; Octamer Transcription Factor-3 - metabolism ; Oncology ; Original Article ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins c-myc - metabolism ; SOXB1 Transcription Factors - metabolism ; Stem cells ; Surgery ; Surgical Oncology</subject><ispartof>Breast cancer (Tokyo, Japan), 2014, Vol.21 (1), p.96-101</ispartof><rights>The Japanese Breast Cancer Society 2012</rights><rights>COPYRIGHT 2014 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-12336741c0147511e6b81edf5cf9338bb6ce6447cd000da816fc196362e401bf3</citedby><cites>FETCH-LOGICAL-c435t-12336741c0147511e6b81edf5cf9338bb6ce6447cd000da816fc196362e401bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22528804$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nagata, Takuya</creatorcontrib><creatorcontrib>Shimada, Yutaka</creatorcontrib><creatorcontrib>Sekine, Shinichi</creatorcontrib><creatorcontrib>Hori, Ryota</creatorcontrib><creatorcontrib>Matsui, Koshi</creatorcontrib><creatorcontrib>Okumura, Tomoyuki</creatorcontrib><creatorcontrib>Sawada, Shigeaki</creatorcontrib><creatorcontrib>Fukuoka, Junya</creatorcontrib><creatorcontrib>Tsukada, Kazuhiro</creatorcontrib><title>Prognostic significance of NANOG and KLF4 for breast cancer</title><title>Breast cancer (Tokyo, Japan)</title><addtitle>Breast Cancer</addtitle><addtitle>Breast Cancer</addtitle><description>Background
Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
Methods
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
Results
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (
P
= 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (
P
= 0.014).
Conclusions
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - mortality</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer patients</subject><subject>Cancer Research</subject><subject>Disease-Free Survival</subject><subject>DNA microarrays</subject><subject>Female</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Kruppel-Like Transcription Factors - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Nanog Homeobox Protein</subject><subject>Octamer Transcription Factor-3 - metabolism</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>SOXB1 Transcription Factors - metabolism</subject><subject>Stem cells</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1340-6868</issn><issn>1880-4233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp9kc1OAyEUhYnR2Fp9ADdmEjduRrnAwDSuGuNfbKwLXROGgQbTQoXpom8vdaqJiTGEcAPfubmcg9Ap4EvAWFwlIKQmJYa8aSXKzR4aQl3jkhFK93NNGS55zesBOkrpHWNGBeaHaEBIRTLHhuj6JYa5D6lzukhu7p11WnltimCL58nz7L5Qvi2epnessCEWTTQqdcUXEo_RgVWLZE525wi93d2-3jyU09n9481kWmpGq66EPAwXDDQGJioAw5saTGsrbceU1k3DteGMCd1ijFtVA7caxpxyYhiGxtIRuuj7rmL4WJvUyaVL2iwWypuwThIYz_g4_yij5z06Vwsjnbehi0pvcTkR2S0hMOGZuvyDyqs1S6eDN9bl-18C6AU6hpSisXIV3VLFjQQst1HIPgqZo5DbKOQma852U6-bpWl_FN_eZ4D0QMpPfm6ifA_r6LOT_3T9BN6rj_E</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Nagata, Takuya</creator><creator>Shimada, Yutaka</creator><creator>Sekine, Shinichi</creator><creator>Hori, Ryota</creator><creator>Matsui, Koshi</creator><creator>Okumura, Tomoyuki</creator><creator>Sawada, Shigeaki</creator><creator>Fukuoka, Junya</creator><creator>Tsukada, Kazuhiro</creator><general>Springer Japan</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Prognostic significance of NANOG and KLF4 for breast cancer</title><author>Nagata, Takuya ; Shimada, Yutaka ; Sekine, Shinichi ; Hori, Ryota ; Matsui, Koshi ; Okumura, Tomoyuki ; Sawada, Shigeaki ; Fukuoka, Junya ; Tsukada, Kazuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-12336741c0147511e6b81edf5cf9338bb6ce6447cd000da816fc196362e401bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - mortality</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer patients</topic><topic>Cancer Research</topic><topic>Disease-Free Survival</topic><topic>DNA microarrays</topic><topic>Female</topic><topic>Homeodomain Proteins - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Kruppel-Like Transcription Factors - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Nanog Homeobox Protein</topic><topic>Octamer Transcription Factor-3 - metabolism</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>SOXB1 Transcription Factors - metabolism</topic><topic>Stem cells</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nagata, Takuya</creatorcontrib><creatorcontrib>Shimada, Yutaka</creatorcontrib><creatorcontrib>Sekine, Shinichi</creatorcontrib><creatorcontrib>Hori, Ryota</creatorcontrib><creatorcontrib>Matsui, Koshi</creatorcontrib><creatorcontrib>Okumura, Tomoyuki</creatorcontrib><creatorcontrib>Sawada, Shigeaki</creatorcontrib><creatorcontrib>Fukuoka, Junya</creatorcontrib><creatorcontrib>Tsukada, Kazuhiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Breast cancer (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nagata, Takuya</au><au>Shimada, Yutaka</au><au>Sekine, Shinichi</au><au>Hori, Ryota</au><au>Matsui, Koshi</au><au>Okumura, Tomoyuki</au><au>Sawada, Shigeaki</au><au>Fukuoka, Junya</au><au>Tsukada, Kazuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of NANOG and KLF4 for breast cancer</atitle><jtitle>Breast cancer (Tokyo, Japan)</jtitle><stitle>Breast Cancer</stitle><addtitle>Breast Cancer</addtitle><date>2014</date><risdate>2014</risdate><volume>21</volume><issue>1</issue><spage>96</spage><epage>101</epage><pages>96-101</pages><issn>1340-6868</issn><eissn>1880-4233</eissn><abstract>Background
Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
Methods
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
Results
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (
P
= 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (
P
= 0.014).
Conclusions
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>22528804</pmid><doi>10.1007/s12282-012-0357-y</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1340-6868 |
| ispartof | Breast cancer (Tokyo, Japan), 2014, Vol.21 (1), p.96-101 |
| issn | 1340-6868 1880-4233 |
| language | eng |
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| source | Springer Nature |
| subjects | Adult Aged Aged, 80 and over Analysis Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Breast Neoplasms - surgery Cancer patients Cancer Research Disease-Free Survival DNA microarrays Female Homeodomain Proteins - metabolism Humans Immunohistochemistry Kruppel-Like Transcription Factors - metabolism Medicine Medicine & Public Health Metastasis Middle Aged Nanog Homeobox Protein Octamer Transcription Factor-3 - metabolism Oncology Original Article Predictive Value of Tests Prognosis Proto-Oncogene Proteins c-myc - metabolism SOXB1 Transcription Factors - metabolism Stem cells Surgery Surgical Oncology |
| title | Prognostic significance of NANOG and KLF4 for breast cancer |
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