Novel inhibitory function of miR-125b in melanogenesis

Summary MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets to treat skin diseases. In this study, miR‐125b was identified as a potent regulator of steady‐state melanogenesis. We found that the expression of miR‐125b was inversely related t...

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Published in:Pigment cell and melanoma research 2014-01, Vol.27 (1), p.140-144
Main Authors: Kim, Kyu-Han, Bin, Bum-Ho, Kim, Juewon, Dong, Son Eui, Park, Phil June, Choi, Hyunjung, Kim, Beom Joon, Yu, Seok Jong, Kang, Hyojin, Kang, Hak Hee, Cho, Eun-Gyung, Lee, Tae Ryong
Format: Article
Language:English
Subjects:
Cell Line
Cyclic AMP - genetics
Cyclic AMP - metabolism
DNA Methylation - physiology
Gene Expression Regulation - physiology
Humans
Medical research
Melanins - biosynthesis
Melanins - genetics
melanogenesis
melanoma
microRNA
MicroRNAs - biosynthesis
MicroRNAs - genetics
miR-125b
Pigmentation - physiology
Promoter Regions, Genetic - physiology
steady-state
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Summary:Summary MicroRNAs are known to be the important regulators of skin physiology and considered as new therapeutic targets to treat skin diseases. In this study, miR‐125b was identified as a potent regulator of steady‐state melanogenesis. We found that the expression of miR‐125b was inversely related to pigment levels. A miR‐125b mimic decreased the expression of pigmentation‐related gene and melanin content, implying that miR‐125b functions to decrease pigmentation. Moreover, we observed that the reduction in miR‐125b expression in pigmented cells was at least partially due to the hypermethylation of the MIR125B‐1 promoter, and miR‐125b expression was regulated by intracellular cAMP levels.
ISSN:1755-1471
1755-148X
DOI:10.1111/pcmr.12179