Biopotentials of secondary metabolites isolated from marine sponges

The secondary metabolites of three sponges collected as bycatch in the fishing nets were explored for biological potencies. The sponge Dendrilla nigraexhibited wider biological activity. It showed potent activity in antibacterial, brineshrimp cytotoxicity, larvicidal, antifouling and ichthyotoxic as...

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Bibliographic Details
Published in:Hydrobiologia 2004-02, Vol.513 (1), p.231-238
Main Authors: SELVIN, Joseph, LIPTON, A. P
Format: Article
Language:English
Subjects:
Antifouling substances
Bacteria
Bioassays
Biodeterioration. Biofouling
Biological and medical sciences
Biotechnology
Bycatch
Cytotoxicity
Fishing nets
Fractionation
Fundamental and applied biological sciences. Psychology
Industrial applications and implications. Economical aspects
Invertebrates
Metabolism
Metabolites
Porifera
Secondary metabolites
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Summary:The secondary metabolites of three sponges collected as bycatch in the fishing nets were explored for biological potencies. The sponge Dendrilla nigraexhibited wider biological activity. It showed potent activity in antibacterial, brineshrimp cytotoxicity, larvicidal, antifouling and ichthyotoxic assays. One of the well-studied cytotoxic sponge Axinella donnaniwas least active in brineshrimp cytotoxicity assay. The secondary metabolites of Clathria gorgonoideswere highly cytotoxic albeit it showed least activity in other bioassays. Based on the present findings, it could be inferred that the bioassay-guided fractionation and purification of D. nigramay come up with potent bioactive drugs. %[PUBLICATION ABSTRACT]
ISSN:0018-8158
1573-5117
DOI:10.1023/B:hydr.0000018183.92410.21