Selection of coxsackievirus B sub(4) variants with monoclonal antibodies results in attenuation

Inoculation of suckling mice with coxsackievirus B sub(4) (CB sub(4)) results in the death of a majority of the animals. In this study the authors selected antigenic variants of CB sub(4) in the presence of neutralizing monoclonal antibodies and tested them to see whether they were attenuated. Antig...

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Bibliographic Details
Published in:Journal of general virology 1987-01, Vol.68 (3), p.865-869
Main Authors: Prabhakar, B S, Srinivasappa, J, Ray, U
Format: Article
Language:English
Online Access:Get full text
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Summary:Inoculation of suckling mice with coxsackievirus B sub(4) (CB sub(4)) results in the death of a majority of the animals. In this study the authors selected antigenic variants of CB sub(4) in the presence of neutralizing monoclonal antibodies and tested them to see whether they were attenuated. Antigenic variants selected with a single antibody showed little or no attenuation by producing a high mortality (60 to 100%). It is concluded that selection of CB sub(4) variants using more than one neutralizing monoclonal antibody can lead to attenuation of the virus.
ISSN:0022-1317