Increases in dopamine utilization in certain limbic dopamine terminal populations after a short period of intermittent exposure of male rats to cigarette smoke

By means of a Walton smoke machine male rats were exposed to cigarette smoke from 1 to 4 cigarettes. Dopamine (DA) levels and utilization in the telencephalon were measured by quantitative histofluorimetry in discrete DA nerve terminal system of the neostriatum, nucleus accumbens and tuberculum olfa...

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Bibliographic Details
Published in:Journal of Neural Transmission 1986-01, Vol.67 (1-2), p.15-29
Main Authors: FUXE, K, ANDERSSON, K, HARFSTRAND, A, AGNATI, L. F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Tobacco, tobacco smoking
Toxicology
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Summary:By means of a Walton smoke machine male rats were exposed to cigarette smoke from 1 to 4 cigarettes. Dopamine (DA) levels and utilization in the telencephalon were measured by quantitative histofluorimetry in discrete DA nerve terminal system of the neostriatum, nucleus accumbens and tuberculum olfactorium. Exposure to unfiltered but not to filtered cigarette smoke resulted in a dose-dependent increase in DA utilization in the diffuse types of DA nerve terminal systems in the anterior nucleus accumbens and the lateral posterior tuberculum olfactorium. After exposure to the smoke from 4 cigarettes also an increase in DA utilization was observed in the dotted type (also cholecystokinin (CCK) positive) of DA nerve terminals of the nucleus accumbens (posterior part).
ISSN:0300-9564
1435-1463
DOI:10.1007/BF01243356