Development of alpha sub(2u)-Globulin Nephropathy and Adrenal Medullary Pheochromocytomas in Male Rats Following Exposure to Stoddard Solvent IIC

• Published in: Inhalation toxicology 2004-05, Vol.16 (5), p.247-247
• Main Authors: Doi, Adriana M, Peckham, John C, Chou, Billy J, Dill, Jeffrey A, Renne, Roger A, Grumbein, Sondra L, Chhabra, Rajendra S
• Format: Article
• Language: English
• ISSN: 0895-8378

Male and female F344/N rats and B6C3F sub(1) mice were exposed to Stoddard solvent IIC for 6 h/d, 5 d/week, for three months or 2 yr, and toxicity and carcinogenicity were assessed. For the shorter period, solvent exposure concentrations were 0, 138, 275, 550, 1100, or 2200 mg/m super(3), and for the 2-yr exposure, the concentrations were 0, 138, 550, 1100, or 2200 mg/m super(3). In both species, kidney was the target of toxicity in males, and exposure-related increases were observed in the incidence and severity of medullary granular casts, hyaline droplet accumulation, and tubular regeneration, along with increases in cell labeling indices and alpha sub(2u)-globulin concentrations, which were suggesting of alpha sub(2u)-globulin-associated nephropathy. Additional evidence of carcinogenicity was based on increases in benign pheochromocytoma and benign or malignant pheochromocytoma following exposure to the middle and high concentrations. Liver was also found to be a site of solvent toxicity in both sexes of both species, as indicated by changes in serum alanine aminotransferase activity and liver weights.