Pharmacological modification of tremor and enhanced acoustic startle by chlordecone and p,p'-DDT

Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals. Pretreatment with an in...

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Bibliographic Details
Published in:Psychopharmacologia 1987-01, Vol.91 (3), p.320-325
Main Authors: HERR, D. W, GALLUS, J. A, TILSON, H. A
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Animals
Biological and medical sciences
Calcium - pharmacology
Chlordecone - toxicity
DDT - toxicity
Injections, Intraventricular
Insecticides - toxicity
Male
Medical sciences
Pesticides, fertilizers and other agrochemicals toxicology
Rats
Rats, Inbred F344
Reflex, Startle - drug effects
Toxicology
Tremor - chemically induced
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Summary:Pretreatment of rats with phenoxybenzamine (5 mg/kg; SC), an alpha adrenergic antagonist, decreased the peak tremor power and startle magnitude of rats subsequently given DDT (75 mg/kg; PO) or chlordecone (60 mg/kg; IP), without having a significant effect on control animals. Pretreatment with an intracerebroventricular injection of calcium (3.75 microM in 5 microliters NaCl) decreased the peak tremor power due to subsequently administered DDT, while increasing the tremor response in rats later dosed with chlordecone. The effects of phenoxybenzamine are postulated to be due to a blockade of an excitatory influence of the adrenergic system. Calcium may decrease DDT-induced tremor by acting as a neuronal stabilizer. Potentiation of the tremorigenic effect of chlordecone by calcium may be due to increased levels of intracellular calcium, resulting in augmented release of neurotransmitters in chlordecone-exposed animals.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00518184