Changes in the adrenals in lead treated rats

Studies addressed the adrenal functions in rats treated with different dosages of lead. Four groups of rats received daily injections of 1, 2, 4, or 6 mg/kg Pb acetate, respectively, over a period of 30 days. Blood and adrenal levels of Pb were significantly higher in animals receiving the higher do...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1986-07, Vol.37 (1), p.62-69
Main Authors: ROY CHOWDHURY, A, GAUTAM, A. K, RAO, R. V, SATHWARA, N. G, PARIKH, D. J, CHATTERJEE, B. B
Format: Article
Language:English
Subjects:
Adrenal Glands - metabolism
Adrenal Glands - pathology
Adrenal Glands - physiopathology
Aminolevulinic Acid - urine
Animals
Ascorbic Acid - metabolism
Biological and medical sciences
Body Weight - drug effects
Catecholamines - metabolism
Chemical and industrial products toxicology. Toxic occupational diseases
Cholesterol - metabolism
Lead - blood
Lead - metabolism
Lead Poisoning - pathology
Lead Poisoning - physiopathology
Male
Medical sciences
Metals and various inorganic compounds
Organ Size - drug effects
Rats
Time Factors
Toxicology
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Summary:Studies addressed the adrenal functions in rats treated with different dosages of lead. Four groups of rats received daily injections of 1, 2, 4, or 6 mg/kg Pb acetate, respectively, over a period of 30 days. Blood and adrenal levels of Pb were significantly higher in animals receiving the higher doses. Significant decreases in adrenal cholesterol and ascorbic acid levels were observed in the groups receiving the two lowest doses. Cytometric findings indicated that the widths of each of the three adrenal cortical zones decreased in groups two, three, and four.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01607730