Immune studies in dioxin-exposed Missouri residents: Quail Run

Altered cell-mediate immune functions were researched in a group of Missouri residents exposed to dioxin-contaminated soil. Cellular immune functions were analyzed in a group of residents from the Quail Run Mobile Home Park. The results of T cell phenotypes showed statistically significant alteratio...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1987-09, Vol.39 (3), p.481-489
Main Authors: KNUTSEN, A. P, ROODMAN, S. T, EVANS, R. G, MUELLER, K. R, WEBB, K. B, STEHR-GREEN, P, HOFFMAN, R. E, SCHRAMM, W. F
Format: Article
Language:English
Subjects:
Biological and medical sciences
Dioxins - toxicity
Environmental pollutants toxicology
General aspects
Humans
Hypersensitivity, Delayed - immunology
Immunity - drug effects
Lymphocyte Activation - drug effects
Medical sciences
Missouri
Polychlorinated Dibenzodioxins - toxicity
T-Lymphocytes - classification
T-Lymphocytes - drug effects
T-Lymphocytes - immunology
Toxicology
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Summary:Altered cell-mediate immune functions were researched in a group of Missouri residents exposed to dioxin-contaminated soil. Cellular immune functions were analyzed in a group of residents from the Quail Run Mobile Home Park. The results of T cell phenotypes showed statistically significant alterations of percentages, but not of absolute numbers of T cell subpopulations in TCDD-exposed subjects. Exposed persons had slightly decreased percentages of T3, T4, and T11 cells. Evidence was found of depressed cellular immunity consistent with that expected from animal studies. The dioxin-exposed population showed evidence for depressed DTH responses to recal antigens.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01688314