Immunohistochemical study of epoxide hydrolase induced by trichloroethylene in rat liver

Epoxide hydrolase catalyzes the hydrolation of potentially toxic, electrophilic epoxides that are often generated during cytochrome P-450 catalyzed monooxigenation, forming the corresponding transdihydrodiols. It is well-known that trichloroethylene is metabolized by cytochrome P-450 containing mix-...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1987-10, Vol.39 (4), p.630-632
Main Authors: KAWAMOTO, T, HOBARA, T, OGINO, K, TAKEMOTO, T, NAKAMURA, K, IMAMURA, A, KOSHIRO, A, KOBAYASHI, H, IWAMOTO, S, SAKAI, T
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Enzyme Induction - drug effects
Epoxide Hydrolases - analysis
Epoxide Hydrolases - biosynthesis
Immunohistochemistry
Liver - enzymology
Male
Medical sciences
Rats
Rats, Inbred Strains
Solvents
Toxicology
Trichloroethylene - poisoning
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Summary:Epoxide hydrolase catalyzes the hydrolation of potentially toxic, electrophilic epoxides that are often generated during cytochrome P-450 catalyzed monooxigenation, forming the corresponding transdihydrodiols. It is well-known that trichloroethylene is metabolized by cytochrome P-450 containing mix-function oxidase systems to trichloroethylene oxide, which decomposes to other metabolites. As trichloroethylene is an epoxide, epoxide hydrolase is suspected to catalyze the hydrolation of trichloroethylene oxide. No reports have appeared about the relationship between trichloroethylene and epoxide hydrolase. In this report, the authors studied the effect of trichloroethylene on epoxide hydrolase immunohistochemically.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01698455