On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes

Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also di...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (98), p.11533-11535
Main Authors: Yellol, Gorakh S, Donaire, Antonio, Yellol, Jyoti G, Vasylyeva, Vera, Janiak, Christoph, Ruiz, José
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Benzimidazoles - chemistry
Benzimidazoles - pharmacology
Cell Cycle - drug effects
Cell Line, Tumor
Cell Survival - drug effects
Coordination Complexes - chemistry
Coordination Complexes - pharmacology
DNA - metabolism
Humans
Iridium - chemistry
Iridium - pharmacology
Protein Binding
Rhodium - chemistry
Rhodium - pharmacology
Ruthenium - chemistry
Ruthenium - pharmacology
Serum Albumin - metabolism
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Summary:Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc46239k