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On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes

Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also di...

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Published in:	Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (98), p.11533-11535
Main Authors:	Yellol, Gorakh S, Donaire, Antonio, Yellol, Jyoti G, Vasylyeva, Vera, Janiak, Christoph, Ruiz, José
Format:	Article
Language:	English
Subjects:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzimidazoles - chemistry Benzimidazoles - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Coordination Complexes - chemistry Coordination Complexes - pharmacology DNA - metabolism Humans Iridium - chemistry Iridium - pharmacology Protein Binding Rhodium - chemistry Rhodium - pharmacology Ruthenium - chemistry Ruthenium - pharmacology Serum Albumin - metabolism
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creator	Yellol, Gorakh S Donaire, Antonio Yellol, Jyoti G Vasylyeva, Vera Janiak, Christoph Ruiz, José
description	Smart design and efficient synthesis of benzimidazole Ru, Ir and Rh cyclometalated complexes are reported with promising cytotoxic activity against HT29, T47D, A2780 and A2780cisR cancer cell lines. Their apoptosis, accumulation, cell cycle arrest, protein binding and DNA binding effects are also discussed.
doi_str_mv	10.1039/c3cc46239k
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subjects	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzimidazoles - chemistry Benzimidazoles - pharmacology Cell Cycle - drug effects Cell Line, Tumor Cell Survival - drug effects Coordination Complexes - chemistry Coordination Complexes - pharmacology DNA - metabolism Humans Iridium - chemistry Iridium - pharmacology Protein Binding Rhodium - chemistry Rhodium - pharmacology Ruthenium - chemistry Ruthenium - pharmacology Serum Albumin - metabolism
title	On the antitumor properties of novel cyclometalated benzimidazole Ru(II), Ir(III) and Rh(III) complexes
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