Iron-catalysed alkene hydrogenation and reductive cross-coupling using a bench-stable iron(ii) pre-catalyst

Operationally simple, iron-catalysed hydrogenation and reductive cross-coupling protocols have been developed using a bench-stable iron(ii) pre-catalyst. The hydrogenation of 18 alkenes (50-99%) and reductive cross-coupling of vinyl halides with aryl- and alkyl Grignard reagents (8 examples, 18-99%)...

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Bibliographic Details
Published in:RSC advances 2013-01, Vol.3 (48), p.25698-25701
Main Authors: Frank, Dominik J., Guiet, Léa, Käslin, Alexander, Murphy, Elliot, Thomas, Stephen P.
Format: Article
Language:English
Subjects:
Alkenes
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Summary:Operationally simple, iron-catalysed hydrogenation and reductive cross-coupling protocols have been developed using a bench-stable iron(ii) pre-catalyst. The hydrogenation of 18 alkenes (50-99%) and reductive cross-coupling of vinyl halides with aryl- and alkyl Grignard reagents (8 examples, 18-99%) is reported using 3 mol% pre-catalyst and hydrogen as stoichiometric reductant (1-50 bar).
ISSN:2046-2069
2046-2069
DOI:10.1039/c3ra44519d