Additional Repression of Activity-Dependent c-fos and BDNF mRNA Expression by Lipophilic Compounds Accompanying a Decrease in Ca super(2+) Influx into Neurons

The influx of calcium ions into cerebellar granule cells of the mouse brain activates the brain derived neurotrophic factor (BDNF) gene due to depolarization of the cell membrane. This can disrupt development of the neonatal mouse brain. A previous study identified permethrin as an environmental dis...

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Bibliographic Details
Published in:Neurotoxicology (Park Forest South) 2005-01, Vol.26 (1), p.17-17
Main Authors: Imamura, Lisa, Kurashina, Kaori, Kawahira, Tomomi, Omoteno, Mitsuki, Tsuda, Masaaki
Format: Article
Language:English
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Summary:The influx of calcium ions into cerebellar granule cells of the mouse brain activates the brain derived neurotrophic factor (BDNF) gene due to depolarization of the cell membrane. This can disrupt development of the neonatal mouse brain. A previous study identified permethrin as an environmental disrupter that suppressed expression of mRNA associated with BDNF and another gene, c-fos. In this study, DDT, diethylstilbestrol (DES), and bisphenol A were investigated for similar suppression of gene expression. When used as a pretreatment, all compounds suppressed gene expression, and calcium ion uptake by the cerebellar granule cells. When the cells were exposed to a combination of DDT, DES, and permethrin, the response was greater than the expected effect, showing that the compounds could active even when below the doses that are considered effective when the compounds are considered individually.
ISSN:0161-813X