CHLOROPOLYSPORINS A, B AND C, NOVEL GLYCOPEPTIDE ANTIBIOTICS FROM FAENIA INTERJECTA SP. NOV: V. COMPARATIVE STUDIES OF THE BIOLOGICAL PROPERTIES

Chloropolysporins A, B and C, as well as derivatives prepared from this group and α-and β-avoparcins by enzymatic and mild acid hydrolysis, were active against Gram-positive bacteria including clinically isolated methicillin-resistant Staphylococci (MIC 0.39 - 6.25 /Jg/ml) and anaerobic enterobacter...

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Published in:Journal of antibiotics 1987/07/25, Vol.40(7), pp.946-952
Main Authors: TAKATSU, TOSHIO, KATAYAMA, TOSHIAKI, NAKAJIMA, MUTSUO, TAKAHASHI, SHUJI, HANEISHI, TATSUO, MAGIRIBUCHI, RERUO, TAJIMA, MASAZO
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Drug Resistance, Microbial
Enterobacteriaceae
Glycopeptides - pharmacology
Gram-Positive Bacteria - drug effects
Medical sciences
Microbial Sensitivity Tests
Micromonosporaceae - analysis
Pharmacology. Drug treatments
Vancomycin - pharmacology
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Summary:Chloropolysporins A, B and C, as well as derivatives prepared from this group and α-and β-avoparcins by enzymatic and mild acid hydrolysis, were active against Gram-positive bacteria including clinically isolated methicillin-resistant Staphylococci (MIC 0.39 - 6.25 /Jg/ml) and anaerobic enterobacteria (MIC 0.10-1.56 μg/ml). Derhamnosyl and demannosyl derivatives from both groups of antibiotics showed stronger activities than the parent compounds. The MIC and MBC values against Staphylococci were similar and were not effected by the presence of serum. Moreover, chloropolysporin C exhibited very strong synergistic effects with various β-lactam antibiotics against methicillin-resistant strains of Staphylococcus aureus. Some of these compounds also protected mice from experimental infection with S. aureus. Acute toxicities of chloropolysporins by intravenous administration ranged from 215-290mg/kg in mice. Chloropolysporin B as well as other glycopeptide antibiotics, showed distinctive growth promoting activity in broiler chickens.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.40.946