Two-dimensional liquid chromatography for direct chiral separations: a review

ABSTRACT Separation of enantiomers remains a challenge owing to their identical physical and chemical properties in an achiral environment, and research on specialized separation techniques such as multidimensional achiral–chiral liquid chromatography continues to resolve individual enantiomers in c...

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Bibliographic Details
Published in:Biomedical chromatography 2014-01, Vol.28 (1), p.59-83
Main Authors: León-González, María Eugenia, Rosales-Conrado, Noelia, Pérez-Arribas, Luis Vicente, Guillén-Casla, Vanesa
Format: Article
Language:English
Subjects:
chiral analysis
Chromatography, Liquid - instrumentation
Chromatography, Liquid - methods
enantiomer separation
multidimensional liquid chromatography
Pesticides - chemistry
Pesticides - isolation & purification
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - isolation & purification
Stereoisomerism
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Summary:ABSTRACT Separation of enantiomers remains a challenge owing to their identical physical and chemical properties in an achiral environment, and research on specialized separation techniques such as multidimensional achiral–chiral liquid chromatography continues to resolve individual enantiomers in complex samples. Recent advances in application of multidimensional liquid chromatography applied to chiral analysis are reviewed. For this reason, benefits of achiral–chiral coupling are shown, with emphasis in applications on biological and pharmaceutical fields as well as pesticide analysis. A description of standard instrumental setup in both heart‐cut and comprehensive multidimensional liquid chromatography is shown. The most broadly used chiral stationary phases for multidimensional liquid chromatography are summarized. An extensive overview of different interface designs applied to complex samples is presented. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.3007